{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:43:24Z","timestamp":1791639804166,"version":"4.3.4"},"reference-count":64,"publisher":"American Physiological Society","issue":"2","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPD1N0481"],"award-info":[{"award-number":["CMRPD1N0481"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC-111-2320-B-182-006-MY2"],"award-info":[{"award-number":["NSTC-111-2320-B-182-006-MY2"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC-112-2320-B-182-028"],"award-info":[{"award-number":["NSTC-112-2320-B-182-028"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTT-113-2320-182-030"],"award-info":[{"award-number":["NSTT-113-2320-182-030"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["BMRP 278"],"award-info":[{"award-number":["BMRP 278"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["BMRPD1M0711"],"award-info":[{"award-number":["BMRPD1M0711"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2025,2,1]]},"abstract":"<jats:p>This study investigates the counteraction of either CAPE or metformin with the AMPK activity increasing GDF15 expression in human bladder cells. The findings are the first study to indicate the secretion of GDF15 from cancer and stroma cells via autocrine or paracrine mechanisms. Our study suggests that GDF15, an antitumor gene in the human bladder induced by AMPK inducers, acts as a communication link between stroma and cancer cells in the human bladder.<\/jats:p>","DOI":"10.1152\/ajpcell.00230.2024","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T13:21:28Z","timestamp":1736774488000},"page":"C557-C573","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Growth differentiation factor 15 is a glucose-downregulated gene acting as the cross talk between stroma and cancer cells of the human bladder"],"prefix":"10.1152","volume":"328","author":[{"given":"Kang-Shuo","family":"Chang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00d80zx46","id-type":"ROR","asserted-by":"publisher"}],"name":"Chang Gung University","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syue-Ting","family":"Chen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00d80zx46","id-type":"ROR","asserted-by":"publisher"}],"name":"Chang Gung University","place":["Taiwan"]},{"id":[{"id":"https:\/\/ror.org\/00d80zx46","id-type":"ROR","asserted-by":"publisher"}],"name":"Chang Gung University","place":["Taiwan"]},{"name":"Chang Gung Memorial Hospital-Linkou","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Yin","family":"Lin","sequence":"additional","affiliation":[{"name":"Chang Gung Memorial Hospital-Linkou","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Yuan","family":"Hsu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00d80zx46","id-type":"ROR","asserted-by":"publisher"}],"name":"Chang Gung University","place":["Taiwan"]},{"id":[{"id":"https:\/\/ror.org\/00d80zx46","id-type":"ROR","asserted-by":"publisher"}],"name":"Chang Gung University","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Ching","family":"Sung","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00d80zx46","id-type":"ROR","asserted-by":"publisher"}],"name":"Chang Gung University","place":["Taiwan"]},{"id":[{"id":"https:\/\/ror.org\/00d80zx46","id-type":"ROR","asserted-by":"publisher"}],"name":"Chang Gung University","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hsiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Chang Gung Memorial Hospital-Linkou","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsui-Hsia","family":"Feng","sequence":"additional","affiliation":[{"name":"Chang Gung University","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Pang","family":"Hou","sequence":"additional","affiliation":[{"name":"Chang Gung Memorial Hospital-Linkou","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8524-8253","authenticated-orcid":false,"given":"Horng-Heng","family":"Juang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00d80zx46","id-type":"ROR","asserted-by":"publisher"}],"name":"Chang Gung University","place":["Taiwan"]},{"id":[{"id":"https:\/\/ror.org\/00d80zx46","id-type":"ROR","asserted-by":"publisher"}],"name":"Chang Gung University","place":["Taiwan"]},{"name":"Chang Gung Memorial Hospital-Linkou","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2171-z"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.699732"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-19-0500"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222011150"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56090441"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2016.03.005"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01039"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2020.10.022"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165960"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.215664"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/srep12870"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2018.04.001"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2018.8498"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2016.02.009"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2021.10.006"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071625"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-014-0562-6"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1346-1"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2019.02.001"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1186\/s41021-017-0074-z"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000966"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-022-01027-2"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-1682"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2017.12.016"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1911-y"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.865988"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00284.2023"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-022-00608-y"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.227900"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55013-0"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2023.02.011"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00180.2011"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911437"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076245"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14020274"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-100910"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3233\/BLC-211653"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000031635"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21552"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_201812_16507"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2023.107059"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.12.008"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1101\/gad.17420111"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12010010"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1080\/09168451.2018.1459179"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020297"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15653"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-015-0183-0"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3897\/pharmacia.66.e38573"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115766"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1007\/s11884-023-00691-w"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3390\/cells10112990"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0530-0"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.21037\/tcr.2017.06.48"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e19802"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5353-6"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12797"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.9.2730"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000139874.48574.1b"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-2259"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25650"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-17-0927"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201855"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-020-00295-x"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00230.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T16:00:29Z","timestamp":1744300829000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00230.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,1]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,1]]}},"alternative-id":["10.1152\/ajpcell.00230.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00230.2024","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,1]]},"assertion":[{"value":"2024-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-17","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}