{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:39:31Z","timestamp":1784893171979,"version":"3.55.0"},"reference-count":98,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL122358"],"award-info":[{"award-number":["R01 HL122358"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK126720"],"award-info":[{"award-number":["R01 DK126720"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01 BX004024"],"award-info":[{"award-number":["I01 BX004024"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R35 HL135749"],"award-info":[{"award-number":["R35 HL135749"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:p> Inwardly rectifying potassium (Kir) channels are broadly expressed in many mammalian organ systems, where they contribute to critical physiological functions. However, the importance and function of the Kir5.1 channel (encoded by the KCNJ16 gene) have not been fully recognized. This review focuses on the recent advances in understanding the expression patterns and functional roles of Kir5.1 channels in fundamental physiological systems vital to potassium homeostasis and neurological disorders. Recent studies have described the role of Kir5.1-forming Kir channels in mouse and rat lines with mutations in the Kcnj16 gene. The animal research reveals distinct renal and neurological phenotypes, including pH and electrolyte imbalances, blunted ventilatory responses to hypercapnia\/hypoxia, and seizure disorders. Furthermore, it was confirmed that these phenotypes are reminiscent of those in patient cohorts in which mutations in the KCNJ16 gene have also been identified, further suggesting a critical role for Kir5.1 channels in homeostatic\/neural systems health and disease. Future studies that focus on the many functional roles of these channels, expanded genetic screening in human patients, and the development of selective small-molecule inhibitors for Kir5.1 channels, will continue to increase our understanding of this unique Kir channel family member. <\/jats:p>","DOI":"10.1152\/ajpcell.00235.2022","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T11:12:22Z","timestamp":1658142742000},"page":"C706-C717","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Kir5.1 channels: potential role in epilepsy and seizure disorders"],"prefix":"10.1152","volume":"323","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5190-8356","authenticated-orcid":false,"given":"Alexander","family":"Staruschenko","sequence":"first","affiliation":[{"name":"Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida"},{"name":"Hypertension and Kidney Research Center, University of South Florida, Tampa, Florida"},{"name":"James A. Haley Veterans Hospital, Tampa, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Hodges","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3680-5527","authenticated-orcid":false,"given":"Oleg","family":"Palygin","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00021.2009"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/164_2021_501"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00016.2014"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-1-14"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-7-143"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000437"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2006.07.005"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00587.x"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00072.2021"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00004.2021"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00523.2019"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.852674"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2020.03.006"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12703"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-5793(01)02202-5"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/joa.13048"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/s0896-6273(02)00675-x"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15080"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00725.x"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.4161\/chan.5176"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2007.04.008"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00363.2013"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00436.2015"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1159\/000369251"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025162"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00288.2007"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15779"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00358.2020"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00420-2"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.630361"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03092.x"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1159\/000015662"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611180104"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2017.03.013"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1159\/000328979"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0222-15.2015"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00560.2002"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00298"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-021-03236-x"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.4161\/chan.3.1.7655"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.60.042307.110802"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00034"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.214759"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2009.04.014"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2010.055848"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1126\/science.1190721"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1268-19.2019"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00544.2010"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23898"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.36428"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-016-1199-8"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-15-05429.2001"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-016-1871-0"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.774585"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.580639"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-009-0165-z"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-016-1600-0"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810276"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1996.271.5.F961"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(01)00241-0"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202114273"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-022-05494-5"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.425"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1003072107"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901749106"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.92331"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1101400108"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1159\/000330250"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12171"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13374"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00112.2016"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-15-05733.2000"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1411705111"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/srep06733"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004835"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020111587"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/nature10370"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1042\/CS20190876"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201802257R"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-021-00883-0"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01899-4"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306596200"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.4.6.753"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.33.4.1043"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1038\/ng0897-387"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.08.043"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.143251"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-021-09877-1"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2010.07.006"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb01519.x"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03358.x"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02908.x"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70214-X"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2006.10.002"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1124\/molpharm.121.000464"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00548.2020"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1124\/mol.118.112359"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.6b00111"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00235.2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T15:11:36Z","timestamp":1718637096000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00235.2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":98,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9,1]]}},"alternative-id":["10.1152\/ajpcell.00235.2022"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00235.2022","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,1]]},"assertion":[{"value":"2022-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-06","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}