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Here we discuss the role of four myokines\u2014fibroblast growth factors (FGF), myostatin, the secreted protein acidic and rich in cysteine (SPARC) miR-29\u2014in tendon development and hypothesize a role for these factors in the progressive changes in tendon structure and function as a result of muscle wasting (disuse, aging, and disease). Because of the close relationship between mechanical loading and muscle and tendon regulation, disentangling muscle-tendon cross talk from simple mechanical loading is experimentally quite difficult. Therefore, we propose an experimental framework that hopefully will be useful in demonstrating muscle-tendon cross talk in vivo. Though understudied, the promise of a better understanding of muscle-tendon cross talk is the development of new interventions that will improve tendon development, regeneration, and function throughout the lifespan. <\/jats:p>","DOI":"10.1152\/ajpcell.00260.2021","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T19:15:53Z","timestamp":1627499753000},"page":"C559-C568","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Muscle-tendon cross talk during muscle wasting"],"prefix":"10.1152","volume":"321","author":[{"given":"Alec M.","family":"Avey","sequence":"first","affiliation":[{"name":"Functional Molecular Biology Laboratory, University of California, Davis, California"},{"name":"Department of Molecular, Cellular, and Integrative Physiology, University of California, Davis, 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