{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T19:09:46Z","timestamp":1778180986353,"version":"3.51.4"},"reference-count":29,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/501100000033","name":"Gouvernement du Canada | IRSC | Institute of Musculoskeletal Health and Arthritis","doi-asserted-by":"publisher","award":["153297"],"award-info":[{"award-number":["153297"]}],"id":[{"id":"10.13039\/501100000033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["1246657"],"award-info":[{"award-number":["1246657"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007613","name":"Majmaah University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007613","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:p> Recent studies reported that in skeletal muscle angiotensin 1\u20137 (Ang 1\u20137), via its receptor Mas (MasR), prevents the atrophy induced by angiotensin II and by cast immobilization; it also improves muscle integrity and function in the mdx mouse, a muscular dystrophy model. The objectives of this study were to document 1) the extent of the Ang 1\u20137\u2019s hypertrophic effect in terms of muscle mass and muscle fiber cross-sectional area (CSA), 2) how Ang 1\u20137 affects muscle contractile function in terms of twitch and tetanic force, force-frequency relationship, and 3) whether the effect involves MasR. Wild-type and MasR-deficient [Mas receptor knockout mouse model ( MasR<jats:sup>\u2212\/\u2212<\/jats:sup>)] mice were treated with Ang 1\u20137 (100 ng\/kg body wt\u00b7min using an osmotic pump) for 4 or 16 wk. Ang 1\u20137 significantly increased skeletal muscle\/body weight ratio of soleus, tibialis, and gastrocnemius, but not of extensor digitorum longus (EDL). It significantly increased fiber cross-sectional area in the order of type I &gt; IIA &gt; IIB. In EDL and soleus muscles, it significantly increased twitch and tetanic force while causing a shift in the force-frequency relationship toward lower stimulation frequencies. It had no effect on fiber type composition. None of the Ang 1\u20137 effects observed in wild-type mice were observed in MasR<jats:sup>\u2212\/\u2212<\/jats:sup> muscles. It caused a transient increase in phosphorylated protein kinase B (Akt) and 4EBP proteins while having no effect on S6 phosphorylation, MuRF-1, and atrogin-1 and a decrease in PAX7 expression in satellite cells. This is the first study demonstrating the hypertrophic effects of Ang 1\u20137 in normal muscle acting via its MasR. <\/jats:p>","DOI":"10.1152\/ajpcell.00271.2021","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T01:44:07Z","timestamp":1666662247000},"page":"C1681-C1696","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Angiotensin 1\u20137 increases fiber cross-sectional area and force in juvenile mouse skeletal muscle"],"prefix":"10.1152","volume":"323","author":[{"given":"Hind","family":"Albadrani","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Department of Medical laboratory Sciences, Majmaah University, Al Majma'ah, Saudi 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