{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T22:26:14Z","timestamp":1787178374155,"version":"build-2736575974"},"reference-count":96,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/501100021954","name":"Tour de Cure","doi-asserted-by":"publisher","award":["RSP-055-FY2024"],"award-info":[{"award-number":["RSP-055-FY2024"]}],"id":[{"id":"10.13039\/501100021954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"DHAC | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP2017070"],"award-info":[{"award-number":["APP2017070"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Training Program Scholarship from the Australian government"}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:p>By modeling cancer-associated cachexia over a time-course in male and female mice, we show that skeletal muscle remodeling begins before overt wasting is evident. The precachectic interval is marked by suppressed protein synthesis, muscle-local immune remodeling, extracellular matrix disruption, and metabolic vulnerability, with several responses differing by sex. These findings suggest that key features of cachexia emerge early in the disease time-course and may inform clinical approaches for detecting disease before significant muscle wasting occurs.<\/jats:p>","DOI":"10.1152\/ajpcell.00271.2026","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:50:36Z","timestamp":1784249436000},"page":"C533-C549","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex-divergent skeletal muscle remodeling emerges early in cancer cachexia"],"prefix":"10.1152","volume":"331","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7063-0162","authenticated-orcid":false,"given":"Chris","family":"Karagiannis","sequence":"first","affiliation":[{"name":"The University of Melbourne","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2549-9859","authenticated-orcid":false,"given":"Alastair A. E.","family":"Saunders","sequence":"additional","affiliation":[{"name":"The University of Melbourne","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3802-8597","authenticated-orcid":false,"given":"Rachel E.","family":"Thomson","sequence":"additional","affiliation":[{"name":"The University of Melbourne","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6269-5130","authenticated-orcid":false,"given":"Mar\u00eda","family":"Guill\u00e1n-Fresco","sequence":"additional","affiliation":[{"name":"The University of Melbourne","place":["Australia"]},{"name":"Santiago University Clinical Hospital SERGAS","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3068-5319","authenticated-orcid":false,"given":"Wayne X.","family":"Du","sequence":"additional","affiliation":[{"name":"The University of Melbourne","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5874-7743","authenticated-orcid":false,"given":"Craig A.","family":"Goodman","sequence":"additional","affiliation":[{"name":"The University of Melbourne","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7418-8945","authenticated-orcid":false,"given":"Paul","family":"Gregorevic","sequence":"additional","affiliation":[{"name":"The University of Melbourne","place":["Australia"]},{"name":"The University of Washington School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.105"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12167"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.7573\/dic.212265"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-010-0002-6"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1080\/14796694.2024.2341576"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14122853"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.21037\/apm.2018.08.07"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-1073-3"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000001054"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2024.02.026"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2008.06.013"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.6043"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2023.112317"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqac251"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.08.002"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2023.101080"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00317.2024"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/cpph.80"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00751.2025"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-023-09462-7"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00442.2010"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0000000000000380"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-020-00628-w"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.28608C"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2332-y"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2011.12.008"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00196.2023"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.16003"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12998"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-014-0141-2"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14010028"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1186\/s13765-019-0417-5"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.1033932"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-363"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/srep26991"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21031092"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.4081\/ejtm.2016.5958"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1101\/gad.412606"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2026.1773275"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay9592"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac4976"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-3152"},{"key":"B44","first-page":"38","volume":"31","author":"Bayly J","year":"2017","journal-title":"Oncology (Williston Park)"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-168799"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.6.1345"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1023\/a:1006961919775"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1289537"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1097\/spc.0b013e3283196ac2"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(04)00400-3"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/s1097-2765(04)00211-4"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2014_9"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00125.2016"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2307"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.11.002"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06581-6"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.399949"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22871"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00410.2012"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.289.6445.584"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980101)82:1<42::AID-CNCR5>3.0.CO;2-M"},{"key":"B62","first-page":"4807","volume":"42","author":"Lundholm K","year":"1982","journal-title":"Cancer Res"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pky043"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3797"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202357695"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2019.101465"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00624-w"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00548.2023"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.livres.2025.10.001"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.03.009"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00230.2025"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1159\/000347132"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13153"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-024-01270-7"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114925"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-08180-0"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14040963"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.54095"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800741124"},{"key":"B80","first-page":"301","volume":"111","author":"Pisters PW","year":"1992","journal-title":"Surgery"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2012.05.003"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/s0899-9007(01)00561-5"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx815"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2023.2197124"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13073"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3859"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2019.07.009"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-02230"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.12.11.18134"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201802799R"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1042\/BST20221066"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020555"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119888"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1111\/joa.70025"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1101\/gad.276733.115"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.960341"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00271.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T22:16:42Z","timestamp":1787177802000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00271.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":96,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9,1]]}},"alternative-id":["10.1152\/ajpcell.00271.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00271.2026","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"assertion":[{"value":"2026-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}