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EphrinB2 promoted osteogenic differentiation of cardiac fibroblasts through activating Ca<jats:sup>2+<\/jats:sup>-related S100\/RAGE signaling. Inhibition of Ca<jats:sup>2+<\/jats:sup> influx using L-type calcium channel blockers inhibited EphrinB2-mediated calcification of cardiac fibroblasts. 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