{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T19:40:42Z","timestamp":1778701242637,"version":"3.51.4"},"reference-count":52,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/501100000038","name":"Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:p> Cardiac contractile function is largely mediated by the regulation of Ca<jats:sup>2+<\/jats:sup> cycling throughout the lifespan. The sarco(endo)plasmic reticulum Ca<jats:sup>2+<\/jats:sup> ATPase (SERCA) pump is paramount to cardiac Ca<jats:sup>2+<\/jats:sup> regulation, and it is well established that SERCA dysfunction pathologically contributes to cardiomyopathy and heart failure. Phospholamban (PLN) is a well-known inhibitor of the SERCA pump and its regulation of SERCA2a\u2014the predominant cardiac SERCA isoform\u2014contributes significantly to proper cardiac function. Glycogen synthase kinase 3 (GSK3) is a serine\/threonine kinase involved in several metabolic pathways, and we and others have shown that it regulates SERCA function. In this mini-review, we highlight the underlying mechanisms behind GSK3\u2019s regulation of SERCA function specifically discussing changes in SERCA2a and PLN expression and its potential protection against oxidative stress. Ultimately, these recent findings that we discuss could have clinical implications in the treatment and prevention of cardiomyopathies and heart failure. <\/jats:p>","DOI":"10.1152\/ajpcell.00318.2020","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T18:41:11Z","timestamp":1596652871000},"page":"C694-C699","source":"Crossref","is-referenced-by-count":30,"title":["The role of phospholamban and GSK3 in regulating rodent cardiac SERCA function"],"prefix":"10.1152","volume":"319","author":[{"given":"Sophie I.","family":"Hamstra","sequence":"first","affiliation":[{"name":"Department of Kinesiology, Brock University, St. Catharines, Ontario, Canada"},{"name":"Centre for Bone and Muscle Health, Brock University, St. Catharines, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kennedy C.","family":"Whitley","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, Brock University, St. Catharines, Ontario, 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