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We hypothesize that this defect in recruitment delays or decreases phagocytosis by macrophages, contributing to the previously observed fibrotic phenotype of these mice. As the primary source of soluble IgM is peritoneal B-1a cells, which are a subset of self-renewing B cells, we analyzed this cell population and observed a significant reduction in B-1a cells in Sca-1<jats:sup>\u2212\/\u2212<\/jats:sup> animals. Interestingly, these mice are protected from ischemia-reperfusion injury, an acute inflammatory reaction also mediated by IgM and C3 complement that has been linked to a deficit in B-1a cells in previous studies. Collectively, these data reveal a novel role for Sca-1 in innate immunity during muscle regeneration and indicate that further elucidation of immuno-myogenic processes will help to better understand and promote muscle regeneration. <\/jats:p>","DOI":"10.1152\/ajpcell.00319.2010","type":"journal-article","created":{"date-parts":[[2010,12,2]],"date-time":"2010-12-02T01:17:16Z","timestamp":1291252636000},"page":"C287-C294","source":"Crossref","is-referenced-by-count":12,"title":["Sca-1 influences the innate immune response during skeletal muscle regeneration"],"prefix":"10.1152","volume":"300","author":[{"given":"Kimberly K.","family":"Long","sequence":"first","affiliation":[{"name":"Boston Medical Center, Department of Medicine, Section of Infectious Diseases, Boston, Massachusetts;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace K.","family":"Pavlath","sequence":"additional","affiliation":[{"name":"Emory University Department of Pharmacology, Atlanta, 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