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The basal levels of mitotically active and quiescent satellite cell (\u221246 and \u221239% vs. +\/+, and \u221240 and \u221230% vs. +\/ op) and myonuclear number (\u221229% vs. +\/+ and \u221228% vs. +\/ op) in fibers of op\/ op mice were significantly less than controls. Fiber length and sarcomere number in op\/ op were also less than +\/+ (\u221222%) and +\/ op (\u221221%) mice. Similar trend was noted in fiber cross-sectional area (CSA, \u221215% vs. +\/+, P = 0.06, and \u221214% vs. +\/ op, P = 0.07). The sizes of myonuclear domain, cytoplasmic volume per myonucleus, were identical in all types of mice. The CSA, length, and the whole number of sarcomeres, myonuclei, and mitotically active and quiescent satellite cells, as well as myonuclear domain, in single muscle fibers were decreased after 10 days of unloading in all types of mice, although all of these parameters in +\/+ and +\/ op mice were increased toward the control values after 10 days of reloading. However, none of these levels in op\/ op mice were recovered. Data suggest that M-CSF and\/or macrophages are important to activate satellite cells, which cause increase of myonuclear number during fiber hypertrophy. However, it is unclear why their responses to general growth and reloading after unloading are different. <\/jats:p>","DOI":"10.1152\/ajpcell.00348.2014","type":"journal-article","created":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T03:04:25Z","timestamp":1426734265000},"page":"C848-C855","source":"Crossref","is-referenced-by-count":3,"title":["Macrophage deficiency in osteopetrotic (<i>op<\/i>\/<i>op<\/i>) mice inhibits activation of satellite cells and prevents hypertrophy in single soleus fibers"],"prefix":"10.1152","volume":"308","author":[{"given":"T.","family":"Ohira","sequence":"first","affiliation":[{"name":"Space Biomedical Research Office, Japan Aerospace Exploration Agency, Tsukuba City, Ibaraki, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. 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