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Specifically, IL-1\u03b2 can downregulate K\n                    <jats:sub>v<\/jats:sub>\n                    1.6 channels and result in RMP depolarization, which increases Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx through Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.2 channels and promotes mitochondrial dysfunction and apoptosis. Downregulation of K\n                    <jats:sub>v<\/jats:sub>\n                    1.6 channels was detected in chondrocytes of osteoarthritis (OA) model mice and OA patients. 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