{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:31:25Z","timestamp":1792787485159,"version":"4.5.0"},"reference-count":81,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/501100024598","name":"BHF | British Heart Foundation Centre of Regenerative Medicine","doi-asserted-by":"publisher","award":["PG\/14\/15\/30691"],"award-info":[{"award-number":["PG\/14\/15\/30691"]}],"id":[{"id":"10.13039\/501100024598","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["204822\/Z\/16\/Z"],"award-info":[{"award-number":["204822\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Leeds PhD Scholarship","id":[{"id":"https:\/\/ror.org\/024mrxd33","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:p>\n                    We constructed exercise mode-specific angiogenic interaction networks (AngioNets) from endurance and resistance training human datasets. Overlapping stimulus-resolved rat transcriptomes onto these AngioNets, we showed that it is possible to promote angiogenesis through multiple stimuli, yet only a subset led to functional improvement. This divergence is explained by changes in local capillary supply, rather than gross capillary number. Across both human AngioNets, hub-set activity linked transcriptomic programs to microvascular structure, modeled tissue PO\n                    <jats:sub>2<\/jats:sub>\n                    , and fatigue resistance.\n                  <\/jats:p>","DOI":"10.1152\/ajpcell.00397.2026","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:39:03Z","timestamp":1790368743000},"page":"C1092-C1108","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["AngioNet: a systems biology approach to regulation of microvascular remodeling in response to skeletal muscle activity"],"prefix":"10.1152","volume":"331","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9385-2584","authenticated-orcid":false,"given":"Roger W. P.","family":"Kissane","sequence":"first","affiliation":[{"name":"University of Liverpool","place":["United Kingdom"]},{"name":"University of Leeds","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0043-1436","authenticated-orcid":false,"given":"Lukas","family":"Steuernagel","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Metabolism Research","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0389-3580","authenticated-orcid":false,"given":"Peter G.","family":"Tickle","sequence":"additional","affiliation":[{"name":"University of Leeds","place":["United Kingdom"]},{"name":"University of Manchester","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8530-2782","authenticated-orcid":false,"given":"Natalie E.","family":"Doody","sequence":"additional","affiliation":[{"name":"University of Leeds","place":["United Kingdom"]},{"name":"St Andrews","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Bonomo","sequence":"additional","affiliation":[{"name":"University of Liverpool","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Falciani","sequence":"additional","affiliation":[{"name":"University of Liverpool","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter K.","family":"Davidsen","sequence":"additional","affiliation":[{"name":"University of Liverpool","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3084-9692","authenticated-orcid":false,"given":"Stuart","family":"Egginton","sequence":"additional","affiliation":[{"name":"University of Leeds","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00054.2021"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13869-w"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06877-w"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00635.2015"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.004"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.1550"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-008-0563-9"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cophys.2019.06.005"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002955"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1113\/JP280899"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12515"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00762.2016"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1113\/JP280684"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26379"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1113\/JP278975"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1113\/JP288043"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1113\/EP091134"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2020.110889"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2010.053421"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12677"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1113\/JP290009"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1042\/CS20050185"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.095596"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1080\/10739680600785717"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12857"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01110.2014"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-8-250"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2024.1338507"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003389"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.5.2004"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199505000-00015"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000079031.22755.63"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.27"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-7-S1-S7"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1111\/joa.13439"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-445x.2002.tb00061.x"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.248051"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.77.3.1317"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1080\/sj.mn.7300100"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00170.2018"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127424"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/19.2.185"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001409"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2007.01723.x"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/380435a0"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2005.09.007"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.279.2.H772"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.117014"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.303352"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-70397-0"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/s0008-6363(00)00282-0"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-023-09870-z"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2013.08.006"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt215"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.07.015"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-022-05128-6"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00634.2010"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00860.2011"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2011.01414.x"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1186\/2045-824X-5-17"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1549-8719.2010.00043.x"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2013.11.002"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1042\/BST20110715"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12728"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00020.2014"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880170607"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00039.2022"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-012-0940-5"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3109\/13813451003652997"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00082.2002"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00217-1"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00901.2010"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-014-0197-3"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00821.2002"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111982"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab224"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2023.09.014"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1113\/JP281377"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1007\/BF00374404"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00397.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:41:39Z","timestamp":1790865699000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00397.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":81,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10,1]]}},"alternative-id":["10.1152\/ajpcell.00397.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00397.2026","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"assertion":[{"value":"2026-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-29","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}