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While glutathione has been traditionally known as an antioxidant defense mechanism that protects the lung tissue from oxidative stress, glutathione more recently has become recognized for its ability to become covalently conjugated to reactive cysteines within proteins, a modification known as S-glutathionylation (or S-glutathiolation or protein mixed disulfide). S-glutathionylation has the potential to change the structure and function of the target protein, owing to its size (the addition of three amino acids) and charge (glutamic acid). S-glutathionylation also protects proteins from irreversible oxidation, allowing them to be enzymatically regenerated. Numerous enzymes have been identified to catalyze the glutathionylation\/deglutathionylation reactions, including glutathione S-transferases and glutaredoxins. Although protein S-glutathionylation has been implicated in numerous biological processes, S-glutathionylated proteomes have largely remained unknown. In this paper, we focus on the pathways that regulate GSH homeostasis, S-glutathionylated proteins, and glutaredoxins, and we review methods required toward identification of glutathionylated proteomes. Finally, we present the latest findings on the role of glutathionylation\/glutaredoxins in various lung diseases: idiopathic pulmonary fibrosis, asthma, and chronic obstructive pulmonary disease. <\/jats:p>","DOI":"10.1152\/ajpcell.00410.2019","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T20:15:21Z","timestamp":1573071321000},"page":"C304-C327","source":"Crossref","is-referenced-by-count":48,"title":["Dysregulation of the glutaredoxin\/<i>S-<\/i>glutathionylation redox axis in lung diseases"],"prefix":"10.1152","volume":"318","author":[{"given":"Shi B.","family":"Chia","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan A.","family":"Elko","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"Aboushousha","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison M.","family":"Manuel","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"van de Wetering","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E.","family":"Druso","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos","family":"van der Velden","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Seward","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Anathy","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles G.","family":"Irvin","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Vermont, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Wai","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Vermont, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0923-0016","authenticated-orcid":false,"given":"Albert","family":"van der Vliet","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne M. 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