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HSD17B13 is associated with the clinical outcome of chronic liver diseases and is therefore a target for the development of drugs. Here, we demonstrate the promising therapeutic effect of BI-3231 as a potent inhibitor of HSD17B13 based on its ability to inhibit triglyceride accumulation in lipid droplets (LDs), restore lipid metabolism and homeostasis, and increase mitochondrial activity in vitro. <\/jats:p>","DOI":"10.1152\/ajpcell.00413.2023","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T09:38:38Z","timestamp":1705311518000},"page":"C880-C892","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["BI-3231, an enzymatic inhibitor of HSD17B13, reduces lipotoxic effects induced by palmitic acid in murine and human hepatocytes"],"prefix":"10.1152","volume":"326","author":[{"given":"Lucia","family":"Alcober-Boquet","sequence":"first","affiliation":[{"name":"Medical Clinic 1, Goethe University Frankfurt, University Hospital, Frankfurt, 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