{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T01:48:35Z","timestamp":1762998515742},"reference-count":37,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:p> Ryanodine receptor (RyR) type 1 (RyR1) exhibits a markedly lower gain of Ca<jats:sup>2+<\/jats:sup>-induced Ca<jats:sup>2+<\/jats:sup> release (CICR) activity than RyR type 3 (RyR3) in the sarcoplasmic reticulum (SR) of mammalian skeletal muscle (selective stabilization of the RyR1 channel), and this reduction in the gain is largely eliminated using 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonic acid (CHAPS). We have investigated whether the hypothesized interdomain interactions within RyR1 are involved in the selective stabilization of the channel using [<jats:sup>3<\/jats:sup>H]ryanodine binding, single-channel recordings, and Ca<jats:sup>2+<\/jats:sup> release from the SR vesicles. Like CHAPS, domain peptide 4 (DP4, a synthetic peptide corresponding to the Leu<jats:sup>2442<\/jats:sup>-Pro<jats:sup>2477<\/jats:sup> region of RyR1), which seems to destabilize the interdomain interactions, markedly stimulated RyR1 but not RyR3. Their activating effects were saturable and nonadditive. Dantrolene, a potent inhibitor of RyR1 used to treat malignant hyperthermia, reversed the effects of DP4 or CHAPS in an identical manner. These findings indicate that RyR1 is activated by DP4 and CHAPS through a common mechanism that is probably mediated by the interdomain interactions. DP4 greatly increased [<jats:sup>3<\/jats:sup>H]ryanodine binding to RyR1 with only minor alterations in the sensitivity to endogenous CICR modulators (Ca<jats:sup>2+<\/jats:sup>, Mg<jats:sup>2+<\/jats:sup>, and adenine nucleotide). However, DP4 sensitized RyR1 four- to six-fold to caffeine in the caffeine-induced Ca<jats:sup>2+<\/jats:sup> release. Thus the gain of CICR activity critically determines the magnitude and threshold of Ca<jats:sup>2+<\/jats:sup> release by drugs such as caffeine. These findings suggest that the low CICR gain of RyR1 is important in normal Ca<jats:sup>2+<\/jats:sup> handling in skeletal muscle and that perturbation of this state may result in muscle diseases such as malignant hyperthermia. <\/jats:p>","DOI":"10.1152\/ajpcell.00415.2004","type":"journal-article","created":{"date-parts":[[2005,5,16]],"date-time":"2005-05-16T19:26:40Z","timestamp":1116271600000},"page":"C1222-C1230","source":"Crossref","is-referenced-by-count":20,"title":["Postulated role of interdomain interactions within the type 1 ryanodine receptor in the low gain of Ca<sup>2+<\/sup>-induced Ca<sup>2+<\/sup> release activity of mammalian skeletal muscle sarcoplasmic reticulum"],"prefix":"10.1152","volume":"288","author":[{"given":"Takashi","family":"Murayama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiharu","family":"Oba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Ikemoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Endo M. Calcium release from the sarcoplasmic reticulum. Physiol Rev 57: 71\u2013108, 1977.","DOI":"10.1152\/physrev.1977.57.1.71"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Fruen BR, Mickelson JR, and Louis CF. Dantrolene inhibition of sarcoplasmic reticulum Ca2+ release by direct and specific action at skeletal muscle ryanodine receptors. J Biol Chem 272: 26965\u201326971, 1997.","DOI":"10.1074\/jbc.272.43.26965"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Gaburjakova M, Gaburjakova J, Reiken S, Huang F, Marx SO, Rosemblit N, and Marks AR. FKBP12 binding modulates ryanodine receptor channel gating. J Biol Chem 276: 16931\u201316935, 2001.","DOI":"10.1074\/jbc.M100856200"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Harafuji H and Ogawa Y. Re-examination of the apparent binding constant of ethylene glycol bis(\u03b2-aminoethyl ether)-N,N,N\u2032,N\u2032-tetraacetic acid with calcium around neutral pH. J Biochem (Tokyo) 87: 1305\u20131312, 1980.","DOI":"10.1093\/oxfordjournals.jbchem.a132868"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Ikemoto N and Yamamoto T. Postulated role of inter-domain interaction within the ryanodine receptor in Ca2+ channel regulation. Trends Cardiovasc Med 10: 310\u2013316, 2000.","DOI":"10.1016\/S1050-1738(01)00067-6"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Ikemoto N and Yamamoto T. Regulation of calcium release by interdomain interaction within ryanodine receptors. Front Biosci 7: d671\u2013d683, 2002.","DOI":"10.2741\/A803"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Kobayashi S, Bannister ML, Gangopadhyay JP, Hamada T, Parness J, and Ikemoto N. Dantrolene stabilizes domain interactions within the ryanodine receptor. J Biol Chem 280: 6580\u20136587, 2005. First published on December 16, 2004; doi:10.1074\/jbc.M408375200.","DOI":"10.1074\/jbc.M408375200"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Kobayashi S, Yamamoto T, Parness J, and Ikemoto N. Antibody probe study of Ca2+ channel regulation by interdomain interaction within the ryanodine receptor. Biochem J 380: 561\u2013569, 2004.","DOI":"10.1042\/bj20040112"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Krause T, Gerbershagen MU, Fiege M, Weisshorn R, and Wappler F. Dantrolene: a review of its pharmacology, therapeutic use and new developments. Anaesthesia 59: 364\u2013373, 2004.","DOI":"10.1111\/j.1365-2044.2004.03658.x"},{"key":"R10","doi-asserted-by":"crossref","unstructured":"Lamb GD, Posterino GS, Yamamoto T, and Ikemoto N. Effects of a domain peptide of the ryanodine receptor on Ca2+ release in skinned skeletal muscle fibers. Am J Physiol Cell Physiol 281: C207\u2013C214, 2001.","DOI":"10.1152\/ajpcell.2001.281.1.C207"},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Marks AR. Cellular functions of immunophilins. Physiol Rev 76: 631\u2013649, 1996.","DOI":"10.1152\/physrev.1996.76.3.631"},{"key":"R12","doi-asserted-by":"crossref","unstructured":"Marks AR. Ryanodine receptors, FKBP12, and heart failure. Front Biosci 7: d970\u2013d977, 2002.","DOI":"10.2741\/A822"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"McCarthy TV, Quane KA, and Lynch PJ. Ryanodine receptor mutations in malignant hyperthermia and central core disease. Hum Mutat 15: 410\u2013417, 2000.","DOI":"10.1002\/(SICI)1098-1004(200005)15:5<410::AID-HUMU2>3.0.CO;2-D"},{"key":"R14","doi-asserted-by":"crossref","unstructured":"Meissner G. Regulation of mammalian ryanodine receptors. Front Biosci 7: d2072\u2013d2080, 2002.","DOI":"10.2741\/A899"},{"key":"R15","doi-asserted-by":"crossref","unstructured":"Meissner G. Ryanodine receptor\/Ca2+ release channels and their regulation by endogenous effectors. Annu Rev Physiol 56: 485\u2013508, 1994.","DOI":"10.1146\/annurev.ph.56.030194.002413"},{"key":"R16","doi-asserted-by":"crossref","unstructured":"Mickelson JR and Louis CF. Malignant hyperthermia: excitation-contraction coupling, Ca2+ release channel, and cell Ca2+ regulation defects. Physiol Rev 76: 537\u2013592, 1996.","DOI":"10.1152\/physrev.1996.76.2.537"},{"key":"R17","doi-asserted-by":"crossref","unstructured":"Murayama T, Oba T, Katayama E, Oyamada H, Oguchi K, Kobayashi M, Otsuka K, and Ogawa Y. Further characterization of the type 3 ryanodine receptor (RyR3) purified from rabbit diaphragm. J Biol Chem 274: 17297\u201317308, 1999.","DOI":"10.1074\/jbc.274.24.17297"},{"key":"R18","doi-asserted-by":"crossref","unstructured":"Murayama T and Ogawa Y. Characterization of type 3 ryanodine receptor (RyR3) of sarcoplasmic reticulum from rabbit skeletal muscles. J Biol Chem 272: 24030\u201324037, 1997.","DOI":"10.1074\/jbc.272.38.24030"},{"key":"R19","doi-asserted-by":"crossref","unstructured":"Murayama T and Ogawa Y. RyR1 exhibits lower gain of CICR activity than RyR3 in the SR: evidence for selective stabilization of RyR1 channel. Am J Physiol Cell Physiol 287: C36\u2013C45, 2004.","DOI":"10.1152\/ajpcell.00395.2003"},{"key":"R20","doi-asserted-by":"crossref","unstructured":"Murayama T and Ogawa Y. Selectively suppressed Ca2+-induced Ca2+ release activity of \u03b1-ryanodine receptor (\u03b1-RyR) in frog skeletal muscle sarcoplasmic reticulum: potential distinct modes in Ca2+ release between \u03b1- and \u03b2-RyR. J Biol Chem 276: 2953\u20132960, 2001.","DOI":"10.1074\/jbc.M005809200"},{"key":"R21","doi-asserted-by":"crossref","unstructured":"Nelson TE. Malignant hyperthermia: a pharmacogenetic disease of Ca2+ regulating proteins. Curr Mol Med 2: 347\u2013369, 2002.","DOI":"10.2174\/1566524023362429"},{"key":"R22","doi-asserted-by":"crossref","unstructured":"Oba T and Maeno Y. Acetaldehyde alters Ca2+-release channel gating and muscle contraction in a dose-dependent manner. Am J Physiol Cell Physiol 286: C1188\u2013C1194, 2004.","DOI":"10.1152\/ajpcell.00388.2003"},{"key":"R23","doi-asserted-by":"crossref","unstructured":"Oba T, Murayama T, and Ogawa Y. Redox states of type 1 ryanodine receptor alter Ca2+ release channel response to modulators. Am J Physiol Cell Physiol 282: C684\u2013C692, 2002.","DOI":"10.1152\/ajpcell.01273.2000"},{"key":"R24","doi-asserted-by":"crossref","unstructured":"Ogawa Y. Role of ryanodine receptors. Crit Rev Biochem Mol Biol 29: 229\u2013274, 1994.","DOI":"10.3109\/10409239409083482"},{"key":"R25","doi-asserted-by":"crossref","unstructured":"Ogawa Y. Some properties of fragmented frog sarcoplasmic reticulum with particular reference to its response to caffeine. J Biochem (Tokyo) 67: 667\u2013683, 1970.","DOI":"10.1093\/oxfordjournals.jbchem.a129295"},{"key":"R26","doi-asserted-by":"crossref","unstructured":"Ohta T, Endo M, Nakano T, Morohoshi Y, Wanikawa K, and Ohga A. Ca2+-induced Ca2+ release in malignant hyperthermia-susceptible pig skeletal muscle. Am J Physiol Cell Physiol 256: C358\u2013C367, 1989.","DOI":"10.1152\/ajpcell.1989.256.2.C358"},{"key":"R27","doi-asserted-by":"crossref","unstructured":"Parness J and Palnitkar SS. Identification of dantrolene binding sites in porcine skeletal muscle sarcoplasmic reticulum. J Biol Chem 270: 18465\u201318472, 1995.","DOI":"10.1074\/jbc.270.31.18465"},{"key":"R28","doi-asserted-by":"crossref","unstructured":"Paul-Pletzer K, Yamamoto T, Bhat MB, Ma J, Ikemoto N, Jimenez LS, Morimoto H, Williams PG, and Parness J. Identification of a dantrolene-binding sequence on the skeletal muscle ryanodine receptor. J Biol Chem 277: 34918\u201334923, 2002.","DOI":"10.1074\/jbc.M205487200"},{"key":"R29","doi-asserted-by":"crossref","unstructured":"Pessah IN, Kim KH, and Feng W. Redox sensing properties of the ryanodine receptor complex. Front Biosci 7: a72-a79, 2002.","DOI":"10.2741\/A741"},{"key":"R30","doi-asserted-by":"crossref","unstructured":"Rios E and Pizarro G. Voltage sensor of excitation-contraction coupling in skeletal muscle. Physiol Rev 71: 849\u2013908, 1991.","DOI":"10.1152\/physrev.1991.71.3.849"},{"key":"R31","doi-asserted-by":"crossref","unstructured":"Schneider MF. Control of calcium release in functioning skeletal muscle fibers. Annu Rev Physiol 56: 463\u2013484, 1994.","DOI":"10.1146\/annurev.ph.56.030194.002335"},{"key":"R32","doi-asserted-by":"crossref","unstructured":"Shtifman A, Ward CW, Yamamoto T, Wang J, Olbinski B, Valdivia HH, Ikemoto N, and Schneider MF. Interdomain interactions within ryanodine receptors regulate Ca2+ spark frequency in skeletal muscle. J Gen Physiol 119: 15\u201332, 2002.","DOI":"10.1085\/jgp.119.1.15"},{"key":"R33","doi-asserted-by":"crossref","unstructured":"Sorrentino V. The ryanodine receptor family of intracellular calcium release channels. Adv Pharmacol 33: 67\u201390, 1995.","DOI":"10.1016\/S1054-3589(08)60666-3"},{"key":"R34","doi-asserted-by":"crossref","unstructured":"Sutko JL and Airey JA. Ryanodine receptor Ca2+ release channels: does diversity in form equal diversity in function? Physiol Rev 76: 1027\u20131071, 1996.","DOI":"10.1152\/physrev.1996.76.4.1027"},{"key":"R35","doi-asserted-by":"crossref","unstructured":"Weber A and Herz R. The relationship between caffeine contracture of intact muscle and the effect of caffeine on reticulum. J Gen Physiol 52: 750\u2013759, 1968.","DOI":"10.1085\/jgp.52.5.750"},{"key":"R36","doi-asserted-by":"crossref","unstructured":"Yamamoto T, El-Hayek R, and Ikemoto N. Postulated role of interdomain interaction within the ryanodine receptor in Ca2+ channel regulation. J Biol Chem 275: 11618\u201311625, 2000.","DOI":"10.1074\/jbc.275.16.11618"},{"key":"R37","doi-asserted-by":"crossref","unstructured":"Yamamoto T and Ikemoto N. Spectroscopic monitoring of local conformational changes during the intramolecular domain-domain interaction of the ryanodine receptor. Biochemistry 41: 1492\u20131501, 2002.","DOI":"10.1021\/bi015581z"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00415.2004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T18:26:40Z","timestamp":1718648800000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00415.2004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.1152\/ajpcell.00415.2004"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00415.2004","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}