{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T06:34:26Z","timestamp":1775975666789,"version":"3.50.1"},"reference-count":51,"publisher":"American Physiological Society","issue":"2","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["K01CA240533"],"award-info":[{"award-number":["K01CA240533"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:p>The mechanism underlying PDAC-associated SMW is not well understood but has been connected to increases in systemic IGFBP-3 to supraphysiologic levels, resulting in dysregulated protein synthesis and catabolism signaling. Here, we show that genetic deletion of IGFBP-3 in orthotopic PDAC tumors significantly improves survival and muscle phenotypes in mice. Molecular studies suggest the role for noncanonical IGFBP-3 signaling through TGF-\u03b2 receptors. Thus, IGFBP-3 may be a therapeutic target in the treatment of PDAC-related SMW.<\/jats:p>","DOI":"10.1152\/ajpcell.00421.2025","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T16:40:20Z","timestamp":1768236020000},"page":"C467-C481","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Ablation of tumor-derived IGFBP-3 attenuates cancer-associated skeletal muscle wasting in murine pancreatic cancer"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0105-9464","authenticated-orcid":false,"given":"Zachary R.","family":"Sechrist","sequence":"first","affiliation":[{"name":"University of Rochester Medical Center","place":["United States"]},{"name":"University of Rochester Medical Center","place":["United States"]},{"name":"University of Rochester Medical Center","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Belcher","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center","place":["United States"]},{"name":"University of Rochester Medical Center","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6676-5345","authenticated-orcid":false,"given":"Nidhi R.","family":"Patel","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center","place":["United States"]},{"name":"University of Rochester","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7749-5263","authenticated-orcid":false,"given":"Zoe J.","family":"Pittman","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center","place":["United States"]},{"name":"University of Rochester","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4854-9698","authenticated-orcid":false,"given":"Edward M.","family":"Schwarz","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center","place":["United States"]},{"name":"University of Rochester Medical Center","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7365-9506","authenticated-orcid":false,"given":"Calvin L.","family":"Cole","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center","place":["United States"]},{"name":"University of Rochester Medical Center","place":["United States"]},{"name":"University of Rochester Medical Center","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0155"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.4708"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2017.01.075"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijso.2016.12.002"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-012-1923-5"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13067"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.17987\/jcsm-cr.v3i2.65"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4887-3"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061543"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/cells9091970"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.638983"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20123-1"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2019.00146"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228592"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00286"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1530\/JME-18-0016"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0400"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00117"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.010389"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15041112"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-020-01389-2"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.04.023"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.081"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12699"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-016-0317-z"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-4439"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317424"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0230695"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.17226\/25801"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2021.100307"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3047"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0292196"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201802799R"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206128"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00345.2024"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnad008"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00009.2004"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1210\/me.2013-1194"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/s1097-2765(02)00585-3"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v14.i12.2302"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3171\/2018.8.JNS181217"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161009"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2013.09.004"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1513-z"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2022.09.003"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7670"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2019.07.009"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.4161\/auto.4600"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2011.03.013"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12891"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00421.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:51:17Z","timestamp":1774533077000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00421.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,1]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,1]]}},"alternative-id":["10.1152\/ajpcell.00421.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00421.2025","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,1]]},"assertion":[{"value":"2025-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}