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These effects manifest by a response that leads to the deposition of fibrotic tissue, attributable to fibroblast dysfunction. Fibroblasts in themselves provide essential functions within organs, which are determined by the specific identity of their subtype. During disease, fibroblast function is further constrained and directed by the niches that form at the sites of injury. This review delves into the origins of fibroblasts in the heart and kidney, their functions in each tissue, and the processes and stressors whereby they become activated to form myofibroblasts. 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