{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:16:26Z","timestamp":1787166986901,"version":"build-2736575974"},"reference-count":48,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL111497"],"award-info":[{"award-number":["HL111497"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL142906"],"award-info":[{"award-number":["HL142906"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2020,2,1]]},"abstract":"<jats:p>\n                    We studied the mechanisms by which carotid body glomus (type 1) cells produce spontaneous Ca\n                    <jats:sup>2+<\/jats:sup>\n                    oscillations in normoxia and hypoxia. In cells perfused with normoxic solution at 37\u00b0C, we observed relatively uniform, low-frequency Ca\n                    <jats:sup>2+<\/jats:sup>\n                    oscillations in &gt;60% of cells, with each cell showing its own intrinsic frequency and amplitude. The mean frequency and amplitude of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    oscillations were 0.6\u2009\u00b1\u20090.1 Hz and 180\u2009\u00b1\u200942 nM, respectively. The duration of each Ca\n                    <jats:sup>2+<\/jats:sup>\n                    oscillation ranged from 14 to 26 s (mean of \u223c20 s). Inhibition of inositol (1,4,5)-trisphosphate receptor and store-operated Ca\n                    <jats:sup>2+<\/jats:sup>\n                    entry (SOCE) using 2-APB abolished Ca\n                    <jats:sup>2+<\/jats:sup>\n                    oscillations. Inhibition of endoplasmic reticulum Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -ATPase (SERCA) using thapsigargin abolished Ca\n                    <jats:sup>2+<\/jats:sup>\n                    oscillations. ML-9, an inhibitor of STIM1 translocation, also strongly reduced Ca\n                    <jats:sup>2+<\/jats:sup>\n                    oscillations. Inhibitors of L- and T-type Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels (Ca\n                    <jats:sub>v<\/jats:sub>\n                    ; verapamil&gt;nifedipine&gt;TTA-P2) markedly reduced the frequency of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    oscillations. Thus, Ca\n                    <jats:sup>2+<\/jats:sup>\n                    oscillations observed in normoxia were caused by cyclical Ca\n                    <jats:sup>2+<\/jats:sup>\n                    fluxes at the ER, which was supported by Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx via Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels. Hypoxia (2\u20135% O\n                    <jats:sub>2<\/jats:sub>\n                    ) increased the frequency and amplitude of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    oscillations, and Ca\n                    <jats:sub>v<\/jats:sub>\n                    inhibitors (verapamil&gt;nifedipine&gt;&gt;TTA-P2) reduced these effects of hypoxia. Our study shows that Ca\n                    <jats:sup>2+<\/jats:sup>\n                    oscillations represent the basic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling mechanism in normoxia and hypoxia in CB glomus cells.\n                  <\/jats:p>","DOI":"10.1152\/ajpcell.00442.2019","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T16:22:19Z","timestamp":1578500539000},"page":"C430-C438","source":"Crossref","is-referenced-by-count":9,"title":["Ca\n                    <sup>2+<\/sup>\n                    oscillations in rat carotid body type 1 cells in normoxia and hypoxia"],"prefix":"10.1152","volume":"318","author":[{"given":"Donghee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James 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