{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:33:55Z","timestamp":1778690035297,"version":"3.51.4"},"reference-count":55,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:p> This study identifies the ZNF197-AS1\/miR-425\/GABARAPL1 axis as a novel regulatory mechanism in uveal melanoma. ZNF197-AS1 upregulates GABARAPL1 by sponging miR-425, inhibiting UM cell proliferation, migration, and invasion. This discovery highlights a potential therapeutic target, providing new insights into UM progression and patient outcomes. <\/jats:p>","DOI":"10.1152\/ajpcell.00457.2024","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T08:00:27Z","timestamp":1727078427000},"page":"C1638-C1650","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["ZNF197-AS1\/miR-425\/GABARAPL1 axis: a novel regulatory mechanism in uveal melanoma"],"prefix":"10.1152","volume":"327","author":[{"given":"Chao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Strabismus and Pediatric Ophthalmology, The Second Hospital of Jilin University, Changchun, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3418-5248","authenticated-orcid":false,"given":"Shuai","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orbital Disease and Ocular Plastic Surgery, The Second Hospital of Jilin University, Changchun, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2019.100800"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-309034"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2020.05.003"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2019-0561-RA"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23116001"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.13140"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.17187"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16122262"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13164041"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.7647"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.686675"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S253946"},{"key":"B13","first-page":"90","volume":"9","author":"Chen X","year":"2017","journal-title":"Am J Transl Res"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3390\/cells8111465"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.24417"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1761-4"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1170265"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-021-00570-6"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6.4.11819"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.4161\/auto.28390"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3390\/biology10100956"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.10.15904"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201600698R"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2016.00236"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbx137"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2022.02.023"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-03688-9"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.854425"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.902577"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.891175"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-01896-x"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.8771"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2016.05.027"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S222564"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.616133"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3390\/genes12071004"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2020.10.009"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-021-00913-w"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.05.082"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15958"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3233\/CBM-190782"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.657984"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2023.01.003"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12123867"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.7150\/jca.51851"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12536"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.842496"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2014.06.030"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa048"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15762"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-1794"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2009.40"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10377.x"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.08.026"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18010226"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00457.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T14:08:47Z","timestamp":1734358127000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00457.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,1]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12,1]]}},"alternative-id":["10.1152\/ajpcell.00457.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00457.2024","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,1]]},"assertion":[{"value":"2024-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}