{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:05:35Z","timestamp":1788865535044,"version":"build-2803163510"},"reference-count":61,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:p>Sj\u00f6gren's syndrome and therapeutic radiation for head and neck cancers result in irreversible changes in the parenchyma of salivary glands, loss of acinar cells, prominence of duct cells, and fibrosis. To clarify mechanisms of salivary gland dysfunction, we identified a signaling pathway involved in the dedifferentiation of primary cultures of parotid acinar cells. We reported previously that the expression pattern of claudins changes during culture, is related to the three-dimensional organization of the cells, and reflects their ability to function as acinar cells. In this study, we found that this change of claudin expression is a process of dedifferentiation, because expression of other differentiation markers also changes during culture. The expression levels of claudins-4 and -6, cytokeratin 14, and vimentin are increased, and those of claudin-10, aquaporin 5, and amylase are decreased. Inhibitors of Src and p38 MAP kinases suppress these changes and increase the expression of acinar marker proteins. Differences in extracellular matrix components have no effect. Activation of p38 MAP kinase occurs during cell isolation from the parotid glands and is retained up to 6 h after the isolation. In contrast, activation of Src kinases does not increase during the cell isolation. The Src inhibitor PP1 suppresses the activation of p38 MAP kinase. Therefore, cellular stresses induced during cell isolation cause dedifferentiation and transition to duct-like cells through activation of p38 MAP kinase and constitutively active Src kinases.<\/jats:p>","DOI":"10.1152\/ajpcell.00472.2007","type":"journal-article","created":{"date-parts":[[2008,1,30]],"date-time":"2008-01-30T20:55:03Z","timestamp":1201726503000},"page":"C774-C785","source":"Crossref","is-referenced-by-count":37,"title":["Inhibition of Src and p38 MAP kinases suppresses the change of claudin expression induced on dedifferentiation of primary cultured parotid acinar cells"],"prefix":"10.1152","volume":"294","author":[{"given":"Junko","family":"Fujita-Yoshigaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miwako","family":"Matsuki-Fukushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Sugiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Abuazza G\n                      , Becker A, Williams SS, Chakravarty S, Truong HT, Lin F, Baum M.\n                      Claudins 6, 9, and 13 are developmentally expressed renal tight junction proteins.\n                      Am J Physiol Renal Physiol\n                      291\n                      : F1132\u2013F1141, 2006.","DOI":"10.1152\/ajprenal.00063.2006"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Argast GM\n                      , Fausto N, Campbell JS.\n                      Inhibition of RIP2\/RICK\/CARDIAK activity by pyridinyl imidazole inhibitors of p38 MAPK.\n                      Mol Cell Biochem\n                      268\n                      : 129\u2013140, 2005.","DOI":"10.1007\/s11010-005-3701-0"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Bain J\n                      , Plater L, Elliott M, Shpiro N, Hastie CJ, McLauchlan H, Klevernic I, Arthur JS, Alessi DR, Cohen P.\n                      The selectivity of protein kinase inhibitors: a further update.\n                      Biochem J\n                      408\n                      : 297\u2013315, 2007.","DOI":"10.1042\/BJ20070797"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Balda MS\n                      , Matter K.\n                      Epithelial cell adhesion and the regulation of gene expression.\n                      Trends Cell Biol\n                      13\n                      : 310\u2013318, 2003.","DOI":"10.1016\/S0962-8924(03)00105-3"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Baum BJ\n                      .\n                      Prospects for re-engineering salivary glands.\n                      Adv Dent Res\n                      14\n                      : 84\u201388, 2000.","DOI":"10.1177\/08959374000140011401"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Bernfeld P\n                      .\n                      Amylase, \u03b1 and \u03b2.\n                      Methods Enzymol\n                      1\n                      : 149\u2013158, 1955.","DOI":"10.1016\/0076-6879(55)01021-5"},{"key":"R7","doi-asserted-by":"crossref","unstructured":"Bhasker S\n                      , Lilly G, Bhussry B.\n                      Regeneration of the salivary glands in the rabbit.\n                      J Dent Res\n                      45\n                      : 37\u201341, 1966.","DOI":"10.1177\/00220345660450012601"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Bissell MJ\n                      , Hall HG, Parry G.\n                      How does the extracellular matrix direct gene expression?\n                      J Theor Biol\n                      99\n                      : 31\u201368, 1982.","DOI":"10.1016\/0022-5193(82)90388-5"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Blanchard AA\n                      , Watson PH, Shiu RP, Leygue E, Nistor A, Wong P, Myal Y.\n                      Differential expression of claudin 1, 3, and 4 during normal mammary gland development in the mouse.\n                      DNA Cell Biol\n                      25\n                      : 79\u201386, 2006.","DOI":"10.1089\/dna.2006.25.79"},{"key":"R10","doi-asserted-by":"crossref","unstructured":"Bouaouina M\n                      , Blouin E, Halbwachs-Mecarelli L, Lesavre P, Rieu P.\n                      TNF-induced \u03b2\n                      2\n                      -integrin activation involves Src kinases and a redox-regulated activation of p38 MAPK.\n                      J Immunol\n                      173\n                      : 1313\u20131320, 2004.","DOI":"10.4049\/jimmunol.173.2.1313"},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Bulavin DV\n                      , Saito S, Hollander MC, Sakaguchi K, Anderson CW, Appella E, Fornace AJ Jr.\n                      Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation.\n                      EMBO J\n                      18\n                      : 6845\u20136854, 1999.","DOI":"10.1093\/emboj\/18.23.6845"},{"key":"R12","doi-asserted-by":"crossref","unstructured":"Burns BF\n                      , Dardick I, Parks WR.\n                      Intermediate filament expression in normal parotid glands and pleomorphic adenomas.\n                      Virchows Arch\n                      413\n                      : 103\u2013112, 1988.","DOI":"10.1007\/BF00749671"},{"key":"R13","unstructured":"Dardick I\n                      .\n                      Histogenesis and morphogenesis of salivary gland neoplasms. In:\n                      Surgical pathology of the salivary glands\n                      , edited by Ellis G, Auclair P, and Gnepp D. Philadelphia: W. D. Saunders, 1991, p. 108\u2013127."},{"key":"R14","doi-asserted-by":"crossref","unstructured":"Denny PC\n                      , Denny PA.\n                      Dynamics of parenchymal cell division, differentiation, and apoptosis in the young adult female mouse submandibular gland.\n                      Anat Rec\n                      254\n                      : 408\u2013417, 1999.","DOI":"10.1002\/(SICI)1097-0185(19990301)254:3<408::AID-AR12>3.0.CO;2-G"},{"key":"R15","doi-asserted-by":"crossref","unstructured":"Fuchs E\n                      .\n                      Keratins and the skin.\n                      Annu Rev Cell Dev Biol\n                      11\n                      : 123\u2013153, 1995.","DOI":"10.1146\/annurev.cellbio.11.1.123"},{"key":"R16","doi-asserted-by":"crossref","unstructured":"Fujita-Yoshigaki J\n                      , Dohke Y, Hara-Yokoyama M, Kamata Y, Kozaki S, Furuyama S, Sugiya H.\n                      Vesicle-associated membrane protein 2 is essential for cAMP-regulated exocytosis in rat parotid acinar cells: the inhibition of cAMP-dependent amylase release by botulinum neurotoxin B.\n                      J Biol Chem\n                      271\n                      : 13130\u201313134, 1996.","DOI":"10.1074\/jbc.271.22.13130"},{"key":"R17","doi-asserted-by":"crossref","unstructured":"Fujita-Yoshigaki J\n                      , Tagashira A, Yoshigaki T, Furuyama S, Sugiya H.\n                      A primary culture of parotid acinar cells retaining capacity for agonists-induced amylase secretion and generation of new secretory granules.\n                      Cell Tissue Res\n                      320\n                      : 455\u2013464, 2005.","DOI":"10.1007\/s00441-005-1076-x"},{"key":"R18","doi-asserted-by":"crossref","unstructured":"Furuse M\n                      , Tsukita S.\n                      Claudins in occluding junctions of humans and flies.\n                      Trends Cell Biol\n                      16\n                      : 181\u2013188, 2006.","DOI":"10.1016\/j.tcb.2006.02.006"},{"key":"R19","doi-asserted-by":"crossref","unstructured":"Hashizume A\n                      , Ueno T, Furuse M, Tsukita S, Nakanishi Y, Hieda Y.\n                      Expression patterns of claudin family of tight junction membrane proteins in developing mouse submandibular gland.\n                      Dev Dyn\n                      231\n                      : 425\u2013431, 2004.","DOI":"10.1002\/dvdy.20142"},{"key":"R20","doi-asserted-by":"crossref","unstructured":"Heiskala M\n                      , Peterson PA, Yang Y.\n                      The roles of claudin superfamily proteins in paracellular transport.\n                      Traffic\n                      2\n                      : 93\u201398, 2001.","DOI":"10.1034\/j.1600-0854.2001.020203.x"},{"key":"R21","doi-asserted-by":"crossref","unstructured":"Hoffman MP\n                      , Nomizu M, Roque E, Lee S, Jung DW, Yamada Y, Kleinman HK.\n                      Laminin-1 and laminin-2 G-domain synthetic peptides bind syndecan-1 and are involved in acinar formation of a human submandibular gland cell line.\n                      J Biol Chem\n                      273\n                      : 28633\u201328641, 1998.","DOI":"10.1074\/jbc.273.44.28633"},{"key":"R22","doi-asserted-by":"crossref","unstructured":"Huang C\n                      , Ma WY, Maxiner A, Sun Y, Dong Z.\n                      p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389.\n                      J Biol Chem\n                      274\n                      : 12229\u201312235, 1999.","DOI":"10.1074\/jbc.274.18.12229"},{"key":"R23","doi-asserted-by":"crossref","unstructured":"Huot J\n                      , Houle F, Marceau F, Landry J.\n                      Oxidative stress-induced actin reorganization mediated by the p38 mitogen-activated protein kinase\/heat shock protein 27 pathway in vascular endothelial cells.\n                      Circ Res\n                      80\n                      : 383\u2013392, 1997.","DOI":"10.1161\/01.RES.80.3.383"},{"key":"R24","doi-asserted-by":"crossref","unstructured":"Ihrler S\n                      , Zietz C, Sendelhofert A, Lang S, Blasenbreu-Vogt S, Lohrs U.\n                      A morphogenetic concept of salivary duct regeneration and metaplasia.\n                      Virchows Arch\n                      440\n                      : 519\u2013526, 2002.","DOI":"10.1007\/s004280100537"},{"key":"R25","doi-asserted-by":"crossref","unstructured":"Kibbey MC\n                      , Royce LS, Dym M, Baum BJ, Kleinman HK.\n                      Glandular-like morphogenesis of the human submandibular tumor cell line A253 on basement membrane components.\n                      Exp Cell Res\n                      198\n                      : 343\u2013351, 1992.","DOI":"10.1016\/0014-4827(92)90389-P"},{"key":"R26","doi-asserted-by":"crossref","unstructured":"Kleinman HK\n                      , Graf J, Iwamoto Y, Kitten GT, Ogle RC, Sasaki M, Yamada Y, Martin GR, Luckenbill-Edds L.\n                      Role of basement membranes in cell differentiation.\n                      Ann NY Acad Sci\n                      513\n                      : 134\u2013145, 1987.","DOI":"10.1111\/j.1749-6632.1987.tb25004.x"},{"key":"R27","doi-asserted-by":"crossref","unstructured":"Kobayashi K\n                      , Utsumi H, Okada M, Sakairi T, Ikeda I, Kusakabe M, Takagi S.\n                      One-step RT-PCR without initial RNA isolation sStep for laser-microdissected tissue sample.\n                      J Vet Med Sci\n                      65\n                      : 917\u2013919, 2003.","DOI":"10.1292\/jvms.65.917"},{"key":"R28","doi-asserted-by":"crossref","unstructured":"Kojima S\n                      , Rahner C, Peng S, Rizzolo LJ.\n                      Claudin 5 is transiently expressed during the development of the retinal pigment epithelium.\n                      J Membr Biol\n                      186\n                      : 81\u201388, 2002.","DOI":"10.1007\/s00232-001-0137-7"},{"key":"R29","doi-asserted-by":"crossref","unstructured":"Lam K\n                      , Zhang L, Bewick M, Lafrenie RM.\n                      HSG cells differentiated by culture on extracellular matrix involves induction of S-adenosylmethione decarboxylase and ornithine decarboxylase.\n                      J Cell Physiol\n                      203\n                      : 353\u2013361, 2005.","DOI":"10.1002\/jcp.20247"},{"key":"R30","doi-asserted-by":"crossref","unstructured":"Lee JM\n                      , Dedhar S, Kalluri R, Thompson EW.\n                      The epithelial-mesenchymal transition: new insights in signaling, development, and disease.\n                      J Cell Biol\n                      172\n                      : 973\u2013981, 2006.","DOI":"10.1083\/jcb.200601018"},{"key":"R31","doi-asserted-by":"crossref","unstructured":"Leoncini P\n                      , Cintorino M, Vindigni C, Leoncini L, Armellini D, Bugnoli M, Skalli O, Gabbiani G.\n                      Distribution of cytoskeletal and contractile proteins in normal and tumour bearing salivary and lacrimal glands.\n                      Virchows Arch\n                      412\n                      : 329\u2013337, 1988.","DOI":"10.1007\/BF00750259"},{"key":"R32","doi-asserted-by":"crossref","unstructured":"Lui WY\n                      , Lee WM, Cheng CY.\n                      Transforming growth factor-\u03b23 perturbs the inter-Sertoli tight junction permeability barrier in vitro possibly mediated via its effects on occludin, zonula occludens-1, and claudin-11.\n                      Endocrinology\n                      142\n                      : 1865\u20131877, 2001.","DOI":"10.1210\/en.142.5.1865"},{"key":"R33","doi-asserted-by":"crossref","unstructured":"Malik RK\n                      , Parsons JT.\n                      Integrin-mediated signaling in normal and malignant cells: a role of protein tyrosine kinases.\n                      Biochim Biophys Acta\n                      1287\n                      : 73\u201376, 1996.","DOI":"10.1016\/0304-419X(96)00008-X"},{"key":"R34","doi-asserted-by":"crossref","unstructured":"Man YG\n                      , Ball WD, Marchetti L, Hand AR.\n                      Contributions of intercalated duct cells to the normal parenchyma of submandibular glands of adult rats.\n                      Anat Rec\n                      263\n                      : 202\u2013214, 2001.","DOI":"10.1002\/ar.1098"},{"key":"R35","doi-asserted-by":"crossref","unstructured":"Matsuzaki T\n                      , Tajika Y, Suzuki T, Aoki T, Hagiwara H, Takata K.\n                      Immunolocalization of the water channel, aquaporin-5 (AQP5), in the rat digestive system.\n                      Arch Histol Cytol\n                      66\n                      : 307\u2013315, 2003.","DOI":"10.1679\/aohc.66.307"},{"key":"R36","doi-asserted-by":"crossref","unstructured":"Mitra SK\n                      , Schlaepfer DD.\n                      Integrin-regulated FAK-Src signaling in normal and cancer cells.\n                      Curr Opin Cell Biol\n                      18\n                      : 516\u2013523, 2006.","DOI":"10.1016\/j.ceb.2006.08.011"},{"key":"R37","doi-asserted-by":"crossref","unstructured":"Moll R\n                      , Franke WW.\n                      Intermediate filaments and their interaction with membranes. The desmosome-cytokeratin filament complex and epithelial differentiation.\n                      Pathol Res Pract\n                      175\n                      : 146\u2013161, 1982.","DOI":"10.1016\/S0344-0338(82)80105-2"},{"key":"R38","doi-asserted-by":"crossref","unstructured":"Obergfell A\n                      , Eto K, Mocsai A, Buensuceso C, Moores SL, Brugge JS, Lowell CA, Shattil SJ.\n                      Coordinate interactions of Csk, Src, and Syk kinases with \u03b1IIb\u03b23 initiate integrin signaling to the cytoskeleton.\n                      J Cell Biol\n                      157\n                      : 265\u2013275, 2002.","DOI":"10.1083\/jcb.200112113"},{"key":"R39","doi-asserted-by":"crossref","unstructured":"Osailan SM\n                      , Proctor GB, Carpenter GH, Paterson KL, McGurk M.\n                      Recovery of rat submandibular salivary gland function following removal of obstruction: a sialometrical and sialochemical study.\n                      Int J Exp Pathol\n                      87\n                      : 411\u2013423, 2006.","DOI":"10.1111\/j.1365-2613.2006.00500.x"},{"key":"R40","doi-asserted-by":"crossref","unstructured":"Peppi M\n                      , Ghabriel MN.\n                      Tissue-specific expression of the tight junction proteins claudins and occludin in the rat salivary glands.\n                      J Anat\n                      205\n                      : 257\u2013266, 2004.","DOI":"10.1111\/j.0021-8782.2004.00332.x"},{"key":"R41","doi-asserted-by":"crossref","unstructured":"Qi B\n                      , Fujita-Yoshigaki J, Michikawa H, Satoh K, Katsumata O, Sugiya H.\n                      Differences in claudin synthesis in primary cultures of acinar cells from rat salivary gland are correlated with the specific three-dimensional organization of the cells.\n                      Cell Tissue Res\n                      329\n                      : 59\u201370, 2007.","DOI":"10.1007\/s00441-007-0389-3"},{"key":"R42","doi-asserted-by":"crossref","unstructured":"Radisky DC\n                      .\n                      Epithelial-mesenchymal transition.\n                      J Cell Sci\n                      118\n                      : 4325\u20134326, 2005.","DOI":"10.1242\/jcs.02552"},{"key":"R43","unstructured":"Schaafsma HE\n                      , Ramaekers FC.\n                      Cytokeratin subtyping in normal and neoplastic epithelium: basic principles and diagnostic applications.\n                      Pathol Annu\n                      29\n                      : 21\u201362, 1994."},{"key":"R44","doi-asserted-by":"crossref","unstructured":"Scott J\n                      , Liu P, Smith PM.\n                      Morphological and functional characteristics of acinar atrophy and recovery in the duct-ligated parotid gland of the rat.\n                      J Dent Res\n                      78\n                      : 1711\u20131719, 1999.","DOI":"10.1177\/00220345990780110801"},{"key":"R45","unstructured":"Seifert G\n                      , Miehlke A, Haubrich J, Chilla R.\n                      Diseases of the salivary glands: pathology, diagnosis, treatment, facial nerve surgery.\n                      Stuttgart: Georg Thieme Verlag, 1986."},{"key":"R46","doi-asserted-by":"crossref","unstructured":"Shackleton M\n                      , Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat ML, Wu L, Lindeman GJ, Visvader JE.\n                      Generation of a functional mammary gland from a single stem cell.\n                      Nature\n                      439\n                      : 84\u201388, 2006.","DOI":"10.1038\/nature04372"},{"key":"R47","doi-asserted-by":"crossref","unstructured":"Singh AB\n                      , Harris RC.\n                      Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells.\n                      J Biol Chem\n                      279\n                      : 3543\u20133552, 2004.","DOI":"10.1074\/jbc.M308682200"},{"key":"R48","unstructured":"Sreebny L\n                      .\n                      Xerostomia: diagnosis, management and clinical complications. In:\n                      Saliva and oral health\n                      (2nd ed.), edited by Edgar W and O'Mullane D. London: British Dental Association, 1996, p. 45\u201350."},{"key":"R49","doi-asserted-by":"crossref","unstructured":"Standish S\n                      , Shafer W.\n                      Serial histologic effects of rat submaxillary and sublingual salivary gland duct and blood vessel ligation.\n                      J Dent Res\n                      36\n                      : 866\u2013879, 1957.","DOI":"10.1177\/00220345570360060801"},{"key":"R50","doi-asserted-by":"crossref","unstructured":"Stupack DG\n                      , Cheresh DA.\n                      Get a ligand, get a life: integrins, signaling and cell survival.\n                      J Cell Sci\n                      115\n                      : 3729\u20133738, 2002.","DOI":"10.1242\/jcs.00071"},{"key":"R51","doi-asserted-by":"crossref","unstructured":"Sugito T\n                      , Kagami H, Hata K, Nishiguchi H, Ueda M.\n                      Transplantation of cultured salivary gland cells into an atrophic salivary gland.\n                      Cell Transplant\n                      13\n                      : 691\u2013699, 2004.","DOI":"10.3727\/000000004783983567"},{"key":"R52","doi-asserted-by":"crossref","unstructured":"Takahashi S\n                      , Nakamura S, Domon T, Yamamoto T, Wakita M.\n                      Active participation of apoptosis and mitosis in sublingual gland regeneration of the rat following release from duct ligation.\n                      J Mol Histol\n                      36\n                      : 199\u2013205, 2005.","DOI":"10.1007\/s10735-005-1764-6"},{"key":"R53","doi-asserted-by":"crossref","unstructured":"Takahashi S\n                      , Shinzato K, Nakamura S, Domon T, Yamamoto T, Wakita M.\n                      The roles of apoptosis and mitosis in atrophy of the rat sublingual gland.\n                      Tissue Cell\n                      34\n                      : 297\u2013304, 2002.","DOI":"10.1016\/S0040816602000034"},{"key":"R54","doi-asserted-by":"crossref","unstructured":"Thiery JP\n                      , Sleeman JP.\n                      Complex networks orchestrate epithelial-mesenchymal transitions.\n                      Nat Rev Mol Cell Biol\n                      7\n                      : 131\u2013142, 2006.","DOI":"10.1038\/nrm1835"},{"key":"R55","doi-asserted-by":"crossref","unstructured":"Thobe BM\n                      , Frink M, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH.\n                      Src family kinases regulate p38 MAPK-mediated IL-6 production in Kupffer cells following hypoxia.\n                      Am J Physiol Cell Physiol\n                      291\n                      : C476\u2013C482, 2006.","DOI":"10.1152\/ajpcell.00076.2006"},{"key":"R56","unstructured":"Turner RJ\n                      .\n                      Ion transport related to fluid secretion in salivary glands. In:\n                      Biology of the salivary glands\n                      , edited by Dobrosielski-Vergona K. Boca Raton, FL: CRC, 1993, p. p. 105\u2013125."},{"key":"R57","doi-asserted-by":"crossref","unstructured":"Ushio-Fukai M\n                      , Alexander RW, Akers M, Griendling KK.\n                      p38 Mitogen-activated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II. Role in vascular smooth muscle cell hypertrophy.\n                      J Biol Chem\n                      273\n                      : 15022\u201315029, 1998.","DOI":"10.1074\/jbc.273.24.15022"},{"key":"R58","doi-asserted-by":"crossref","unstructured":"Volonte D\n                      , Galbiati F, Pestell RG, Lisanti MP.\n                      Cellular stress induces the tyrosine phosphorylation of caveolin-1 (Tyr\n                      14\n                      ) via activation of p38 mitogen-activated protein kinase and c-Src kinase. Evidence for caveolae, the actin cytoskeleton, and focal adhesions as mechanical sensors of osmotic stress.\n                      J Biol Chem\n                      276\n                      : 8094\u20138103, 2001.","DOI":"10.1074\/jbc.M009245200"},{"key":"R59","doi-asserted-by":"crossref","unstructured":"Wei C\n                      , Larsen M, Hoffman MP, Yamada KM.\n                      Self-organization and branching morphogenesis of primary salivary epithelial cells.\n                      Tissue Eng\n                      13\n                      : 721\u2013735, 2007.","DOI":"10.1089\/ten.2006.0123"},{"key":"R60","doi-asserted-by":"crossref","unstructured":"Windheim M\n                      , Lang C, Peggie M, Plater LA, Cohen P.\n                      Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide.\n                      Biochem J\n                      404\n                      : 179\u2013190, 2007.","DOI":"10.1042\/BJ20061704"},{"key":"R61","doi-asserted-by":"crossref","unstructured":"Zhuang S\n                      , Yan Y, Han J, Schnellmann RG.\n                      p38 kinase-mediated transactivation of the epidermal growth factor receptor is required for dedifferentiation of renal epithelial cells after oxidant injury.\n                      J Biol Chem\n                      280\n                      : 21036\u201321042, 2005.","DOI":"10.1074\/jbc.M413300200"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00472.2007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T13:26:34Z","timestamp":1718630794000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00472.2007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1152\/ajpcell.00472.2007"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00472.2007","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}