{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:40:11Z","timestamp":1788867611497,"version":"build-2803163510"},"reference-count":45,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000069","name":"HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR075794-01A1\/AR\/NIAMS"],"award-info":[{"award-number":["R01AR075794-01A1\/AR\/NIAMS"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM125503"],"award-info":[{"award-number":["P20GM125503"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:p> Herein, we assess the efficacy of the mitochondria-targeted antioxidant SkQ1 to mitigate cancer cachexia (CC) in both biological sexes. We demonstrate that SkQ1 administration attenuates muscle wasting induced by C26 tumors in male, but not female, mice. Conversely, we identify that in females, SkQ1 improves muscle contractility. These phenotypic adaptations to SkQ1 are aligned with respective responses in muscle protein synthesis, mitochondrial respiration, and mRNA content of protein turnover, as well as mitochondrial and calcium handling-related markers. <\/jats:p>","DOI":"10.1152\/ajpcell.00497.2024","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T08:00:37Z","timestamp":1727683237000},"page":"C1308-C1322","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice"],"prefix":"10.1152","volume":"327","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6753-5945","authenticated-orcid":false,"given":"Stavroula","family":"Tsitkanou","sequence":"first","affiliation":[{"name":"Cachexia Research Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5019-2125","authenticated-orcid":false,"given":"Francielly","family":"Morena da Silva","sequence":"additional","affiliation":[{"name":"Cachexia Research Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9811-3585","authenticated-orcid":false,"given":"Ana Regina","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Cachexia Research Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor R.","family":"Schrems","sequence":"additional","affiliation":[{"name":"Exercise Muscle Biology Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruqaiza","family":"Muhyudin","sequence":"additional","affiliation":[{"name":"Cachexia Research Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4797-5265","authenticated-orcid":false,"given":"Pieter J.","family":"Koopmans","sequence":"additional","affiliation":[{"name":"Molecular Muscle Mass Regulation Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States"},{"name":"Cell and Molecular Biology Graduate Program, University of Arkansas, Fayetteville, Arkansas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabin","family":"Khadgi","sequence":"additional","affiliation":[{"name":"Molecular Muscle Mass Regulation Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7075-5909","authenticated-orcid":false,"given":"Seongkyun","family":"Lim","sequence":"additional","affiliation":[{"name":"Cachexia Research Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca J.","family":"Delfinis","sequence":"additional","affiliation":[{"name":"Muscle Health Research Centre and the School of Kinesiology & Health Sciences, Faculty of Health, York University, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1919-5907","authenticated-orcid":false,"given":"Tyrone A.","family":"Washington","sequence":"additional","affiliation":[{"name":"Exercise Muscle Biology Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2783-7137","authenticated-orcid":false,"given":"Kevin A.","family":"Murach","sequence":"additional","affiliation":[{"name":"Molecular Muscle Mass Regulation Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States"},{"name":"Cell and Molecular Biology Graduate Program, University of Arkansas, Fayetteville, Arkansas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5745-5888","authenticated-orcid":false,"given":"Christopher G. R.","family":"Perry","sequence":"additional","affiliation":[{"name":"Muscle Health Research Centre and the School of Kinesiology & Health Sciences, Faculty of Health, York University, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9621-2005","authenticated-orcid":false,"given":"Nicholas P.","family":"Greene","sequence":"additional","affiliation":[{"name":"Cachexia Research Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3829"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-020-00628-w"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00196.2023"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00716.2007"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.12.015"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00660.2021"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12232"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1863414"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00300.2010"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.155147"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.861622"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13040850"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2017.05.005"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2082561"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3791\/54893"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6408278"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101174"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21764"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21327"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12470"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00591.2011"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90872.2008"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12354"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2063179"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1134\/s000629791003003x"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1134\/S1607672912060087"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2008.12.008"},{"key":"B29","first-page":"89","volume":"59","author":"Anikin IV","year":"2013","journal-title":"Vopr Onkol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8837893"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100772"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2022-0086"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04369-z"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30404"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-023-06759-2"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.1047909"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-018-0525-4"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182190b62"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13349"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-01068-4"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1186\/s13395-021-00280-7"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.04.001"},{"key":"B43","first-page":"430","volume":"23","author":"Iurova MH","year":"2010","journal-title":"Adv Gerontol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1134\/S0006297914100162"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001916"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00497.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T17:50:34Z","timestamp":1730829034000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00497.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,1]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,11,1]]}},"alternative-id":["10.1152\/ajpcell.00497.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00497.2024","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,1]]},"assertion":[{"value":"2024-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-03","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}