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However, this gasotransmitter is also endogenously generated by the actions of cystathionine-\u03b2-synthase (CBS), cystathionine-\u03b3-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST) in mammalian systems, thus belonging to the family of gasotransmitters after nitric oxide (NO) and carbon monoxide (CO). The physiological or pathological significance of H\n                    <jats:sub>2<\/jats:sub>\n                    S has been extensively expanded for decades. Growing evidence has revealed that H\n                    <jats:sub>2<\/jats:sub>\n                    S exerts cytoprotective functions in the cardiovascular, nervous, and gastrointestinal systems by modulating numerous signaling pathways. With the continuous advancement of microarray and next-generation sequencing technologies, noncoding RNAs (ncRNAs) have gained recognition as key players in human health and diseases due to their considerable potential as predictive biomarkers and therapeutic targets. Coincidentally, H\n                    <jats:sub>2<\/jats:sub>\n                    S and ncRNAs are not independent regulators but interact with each other during the development and progression of human diseases. Specifically, ncRNAs might serve as downstream mediators of H\n                    <jats:sub>2<\/jats:sub>\n                    S or act on H\n                    <jats:sub>2<\/jats:sub>\n                    S-generating enzymes to govern endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S production. The purpose of this review is to summarize the interactive regulatory roles of H\n                    <jats:sub>2<\/jats:sub>\n                    S and ncRNAs in the initiation and development of various diseases and explore their potential health and therapeutic benefits. This review will also highlight the importance of cross talk between H\n                    <jats:sub>2<\/jats:sub>\n                    S and ncRNAs in disease therapy.\n                  <\/jats:p>","DOI":"10.1152\/ajpcell.00507.2022","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T22:00:33Z","timestamp":1678140033000},"page":"C856-C877","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Hydrogen sulfide in health and diseases: cross talk with noncoding RNAs"],"prefix":"10.1152","volume":"324","author":[{"given":"Qing-Bo","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Endocrine, Affiliated Hospital of Jiangnan University, Jiangnan University, Wuxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of Jiangnan 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