{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:40:25Z","timestamp":1789072825772,"version":"build-2803163510"},"reference-count":50,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070251"],"award-info":[{"award-number":["82070251"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270515"],"award-info":[{"award-number":["82270515"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700412"],"award-info":[{"award-number":["81700412"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200538"],"award-info":[{"award-number":["82200538"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:p>This article illustrates the role of macrophage-derived heme oxygenase-1 (HO-1) in the development of abdominal aortic aneurysm (AAA). HO-1 deletion in macrophages hindered AAA development by reducing inducible nitric oxide synthase (iNOS)-dependent peroxynitrite production and smooth muscle cells (SMCs) apoptosis in vivo. Mechanistically, inhibition of HO-1 reduced the stimulated iNOS protein production in macrophages by lipopolysaccharide\/interferon-\u03b3. Moreover, suppressing iNOS in macrophages prevented SMCs apoptosis by decreasing nitric oxide generation in vitro.<\/jats:p>","DOI":"10.1152\/ajpcell.00525.2023","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T10:51:04Z","timestamp":1745319064000},"page":"C1808-C1821","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Macrophage heme oxygenase-1 modulates peroxynitrite-mediated vascular injury and exacerbates abdominal aortic aneurysm development"],"prefix":"10.1152","volume":"328","author":[{"given":"Liangliang","family":"Jia","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/059cjpv64","id-type":"ROR","asserted-by":"publisher"}],"name":"The Second Affiliated Hospital, Zhejiang University School of Medicine","place":["People\u2019s Republic of China"]},{"name":"State Key Laboratory of Transvascular Implantation Devices","place":["People\u2019s Republic of China"]},{"name":"Cardiovascular Key Laboratory of Zhejiang Province","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Wang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/059cjpv64","id-type":"ROR","asserted-by":"publisher"}],"name":"The Second Affiliated Hospital, Zhejiang University School of Medicine","place":["People\u2019s Republic of China"]},{"name":"State Key Laboratory of Transvascular Implantation Devices","place":["People\u2019s Republic of China"]},{"name":"Cardiovascular Key Laboratory of Zhejiang Province","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunna","family":"Jin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/059cjpv64","id-type":"ROR","asserted-by":"publisher"}],"name":"The Second Affiliated Hospital, Zhejiang University School of Medicine","place":["People\u2019s Republic of China"]},{"name":"State Key Laboratory of Transvascular Implantation Devices","place":["People\u2019s Republic of China"]},{"name":"Cardiovascular Key Laboratory of Zhejiang Province","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuankun","family":"Ma","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/059cjpv64","id-type":"ROR","asserted-by":"publisher"}],"name":"The Second Affiliated Hospital, Zhejiang University School of Medicine","place":["People\u2019s Republic of China"]},{"name":"State Key Laboratory of Transvascular Implantation Devices","place":["People\u2019s Republic of China"]},{"name":"Cardiovascular Key Laboratory of Zhejiang Province","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidong","family":"Wang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/059cjpv64","id-type":"ROR","asserted-by":"publisher"}],"name":"The Second Affiliated Hospital, Zhejiang University School of Medicine","place":["People\u2019s Republic of China"]},{"name":"State Key Laboratory of Transvascular Implantation Devices","place":["People\u2019s Republic of China"]},{"name":"Cardiovascular Key Laboratory of Zhejiang Province","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuguang","family":"Song","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/059cjpv64","id-type":"ROR","asserted-by":"publisher"}],"name":"The Second Affiliated Hospital, Zhejiang University School of Medicine","place":["People\u2019s Republic of China"]},{"name":"State Key Laboratory of Transvascular Implantation Devices","place":["People\u2019s Republic of China"]},{"name":"Cardiovascular Key Laboratory of Zhejiang Province","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Shen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/059cjpv64","id-type":"ROR","asserted-by":"publisher"}],"name":"The Second Affiliated Hospital, Zhejiang University School of Medicine","place":["People\u2019s Republic of China"]},{"name":"State Key Laboratory of Transvascular Implantation Devices","place":["People\u2019s Republic of China"]},{"name":"Cardiovascular Key Laboratory of Zhejiang Province","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Xie","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/059cjpv64","id-type":"ROR","asserted-by":"publisher"}],"name":"The Second Affiliated Hospital, Zhejiang University School of Medicine","place":["People\u2019s Republic of China"]},{"name":"State Key Laboratory of Transvascular Implantation Devices","place":["People\u2019s Republic of China"]},{"name":"Cardiovascular Key Laboratory of Zhejiang Province","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0255-6056","authenticated-orcid":false,"given":"Meixiang","family":"Xiang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/059cjpv64","id-type":"ROR","asserted-by":"publisher"}],"name":"The Second Affiliated Hospital, Zhejiang University School of Medicine","place":["People\u2019s Republic of China"]},{"name":"State Key Laboratory of Transvascular Implantation Devices","place":["People\u2019s Republic of China"]},{"name":"Cardiovascular Key Laboratory of Zhejiang Province","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305269"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0114-9"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2010.09.011"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2018.09.020"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.52"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.08.016"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-015-2539-3"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100484R"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2015.01.003"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.10.411"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11071394"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2019.1587168"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00491-x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.121.315805"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.312910"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.04.043"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3153"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.023789"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.309524"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.171488"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3791\/64173"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.321722"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304927"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2012.01.038"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2001.111805"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2004.12.003"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000269"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.09.009"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.183959"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2015.06.011"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00825"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv114"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9111150"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/s0049-3848(02)00100-7"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000042082.38014.ea"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149288"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11917"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.022747"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3390\/cells10010163"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-021-00363-1"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/nri3073"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgg.2018.01.002"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112712"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202101576R"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.312023"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/s0741-5214(03)00148-4"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218257"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07495-1"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1023\/a:1008942828960"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.08.024"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00525.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T12:17:48Z","timestamp":1749644268000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00525.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,1]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6,1]]}},"alternative-id":["10.1152\/ajpcell.00525.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00525.2023","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,1]]},"assertion":[{"value":"2023-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-01","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}