{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:17:43Z","timestamp":1785237463898,"version":"3.55.0"},"reference-count":40,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/501100018634","name":"State Key Laboratory of Ophthalmology","doi-asserted-by":"publisher","award":["Fundamental Research Funds"],"award-info":[{"award-number":["Fundamental Research Funds"]}],"id":[{"id":"10.13039\/501100018634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018634","name":"State Key Laboratory of Ophthalmology","doi-asserted-by":"publisher","award":["Open Research Funds"],"award-info":[{"award-number":["Open Research Funds"]}],"id":[{"id":"10.13039\/501100018634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"GDSTC | Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2020A1515010144"],"award-info":[{"award-number":["2020A1515010144"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"GDSTC | Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515010513"],"award-info":[{"award-number":["2021A1515010513"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"GDSTC | Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515012442"],"award-info":[{"award-number":["2022A1515012442"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670874"],"award-info":[{"award-number":["81670874"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670885"],"award-info":[{"award-number":["81670885"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:p> To explore the possibility of constructing reliable research carriers on age-related macular degeneration (AMD), iron ion overload was applied to establish models in vitro and in vivo. Subsequent investigations into cellular physiology and molecular biology confirmed the presence of senescence in these models. Through this study, we hope to provide a better option of feasible methods for future researches into AMD. <\/jats:p>","DOI":"10.1152\/ajpcell.00532.2023","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T09:29:59Z","timestamp":1708939799000},"page":"C1367-C1383","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Establishing chronic models of age-related macular degeneration via long-term iron ion overload"],"prefix":"10.1152","volume":"326","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7359-6816","authenticated-orcid":false,"given":"Hao","family":"Huang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"},{"name":"Department of Ophthalmology, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingshu","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Du","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaojuan","family":"Wen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Mao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xielan","family":"Kuang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"},{"name":"Biobank of Eye, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0072-0214","authenticated-orcid":false,"given":"Huijun","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"},{"name":"Eye Fundus Department, Affiliated Aier Eye Hospital of Wuhan University, Wuhan, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9380-9539","authenticated-orcid":false,"given":"Bowen","family":"Li","sequence":"additional","affiliation":[{"name":"Eye Center of Xiangya Hospital, Central South University, Changsha, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongde","family":"Long","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6552-9541","authenticated-orcid":false,"given":"Huangxuan","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"},{"name":"Biobank of Eye, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-vision-100419-114940"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.14336\/ad.2014.0500101"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.04.005"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.10.040"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2021.01.003"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2018.04.006"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2011.02179.x"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2010.02.002"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27935-9"},{"key":"B10","volume-title":"Brain Iron: Neurochemical and Behavioural Aspects","author":"Wigglesworth J","year":"1988"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.14336\/ad.2020.0912"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6113"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14568"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.02.042"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4609702"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/345458a0"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.4161\/cc.24637"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.11613\/bm.2019.030501"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-019-09853-y"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/cells10020369"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/s0891-5849(02)00959-0"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1997.0367"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18030503"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.4137\/oed.s32200"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/35053256"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.03.002"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11030592"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2015.05.019"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405146101"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.19-28250"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12757"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1159\/000517520"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2062887"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05121-z"},{"key":"B35","first-page":"583","volume":"17","author":"Feeney L","year":"1978","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3109\/10799893.2015.1030412"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-081720-114505"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071239"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4956080"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1134\/s0006297923020025"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00532.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T14:44:13Z","timestamp":1718635453000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00532.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,1]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5,1]]}},"alternative-id":["10.1152\/ajpcell.00532.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00532.2023","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,1]]},"assertion":[{"value":"2023-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}