{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T03:59:54Z","timestamp":1782446394790,"version":"3.54.5"},"reference-count":56,"publisher":"American Physiological Society","issue":"4","funder":[{"name":"Ministry of Science, Technological Development and Innovation of Republic of Serbia","award":[". 451-03-136\/2025-03\/2000053"],"award-info":[{"award-number":[". 451-03-136\/2025-03\/2000053"]}]},{"name":"Ministry of Science, Technological Development and Innovation of Republic of Serbia","award":["451-03-137\/2025-03\/200178"],"award-info":[{"award-number":["451-03-137\/2025-03\/200178"]}]},{"name":"Ministry of Science, Technological Development and Innovation of Republic of Serbia","award":["451-03-137\/2025-03\/200178"],"award-info":[{"award-number":["451-03-137\/2025-03\/200178"]}]},{"name":"Ministry of Science, Technological Development and Innovation of Republic of Serbia","award":["451-03-137\/2025-03\/200178"],"award-info":[{"award-number":["451-03-137\/2025-03\/200178"]}]},{"name":"Ministry of Science, Technological Development and Innovation of Republic of Serbia","award":[". 451-03-136\/2025-03\/2000053"],"award-info":[{"award-number":[". 451-03-136\/2025-03\/2000053"]}]},{"name":"Ministry of Science, Technological Development and Innovation of Republic of Serbia","award":["451-03-136\/2025-03\/200007"],"award-info":[{"award-number":["451-03-136\/2025-03\/200007"]}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:p> This study reveals adjustments of astrocyte activity in response to neurotransmitter norepinephrine. We provide compelling demonstration that norepinephrine-induced intracellular Ca<jats:sup>2+<\/jats:sup> increase is coupled with BK channel activation in cultured cortical astrocytes. Our results further indicate that norepinephrine-induced astrocytic Ca<jats:sup>2+<\/jats:sup>-BK channel signaling participates in modulation of capillary diameter in the cortex. These findings provide better understanding of astrocyte communication with neurons and blood vessels. <\/jats:p>","DOI":"10.1152\/ajpcell.00538.2025","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T17:30:48Z","timestamp":1756143048000},"page":"C1061-C1074","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Norepinephrine-induced intracellular Ca<sup>2+<\/sup> increase is coupled with astrocytic BK channel activation and capillary response"],"prefix":"10.1152","volume":"329","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4322-7208","authenticated-orcid":false,"given":"Jelena","family":"Bogdanovi\u0107 Pristov","sequence":"first","affiliation":[{"name":"Institute for Multidisciplinary Research, University of Belgrade","place":["Republic of Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9593-8231","authenticated-orcid":false,"given":"Danijela","family":"Batavelji\u0107","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Biochemistry \u201cJean Giaja\u201d, Faculty of Biology, University of Belgrade","place":["Republic of Serbia"]},{"name":"University of Antwerp","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7479-0186","authenticated-orcid":false,"given":"Dunja","family":"Bijeli\u0107","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Biochemistry \u201cJean Giaja\u201d, Faculty of Biology, University of Belgrade","place":["Republic of Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7360-6853","authenticated-orcid":false,"given":"Katarina","family":"Mili\u0107evi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Biochemistry \u201cJean Giaja\u201d, Faculty of Biology, University of Belgrade","place":["Republic of Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3802-6009","authenticated-orcid":false,"given":"Jelena","family":"Kora\u0107 Ja\u010di\u0107","sequence":"additional","affiliation":[{"name":"Institute for Multidisciplinary Research, University of Belgrade","place":["Republic of Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8575-7824","authenticated-orcid":false,"given":"Ljiljana","family":"Nikoli\u0107","sequence":"additional","affiliation":[{"name":"Institute for Biological Research \u201cSini\u0161a Stankovi\u0107\u201d, National Institute of Republic of Serbia, University of Belgrade","place":["Republic of Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.22-01-00183.2002"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2012.07664.x"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2016.12.002"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20029"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03266-3"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2009.05.001"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20990"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110599"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020388"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4262"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1126\/science.adq5480"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/nature02827"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fnetp.2023.1162757"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2929"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11793-x"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0914722107"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1782-16.2016"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2020.104942"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.04.038"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.15-08-05535.1995"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22414"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24699"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.24066"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2014.019"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.02.037"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-021-02642-y"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2010.03.019"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2013.09.001"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.639754"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00225.2010"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/nn1779"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21160"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1117\/1.nph.2.4.041402"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199708000-00008"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/nature05193"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/nature13165"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X231152549"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav9518"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.251542998"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2023749118"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.18-14-05225.1998"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci15020099"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/nature08673"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.04.003"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23830"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4178-07.2008"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440030612"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn040"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/nn1498"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2013.04.004"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00330.2021"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.18-12-04425.1998"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.17-18-06850.1997"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2001.281.4.c1373"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-012-0818-x"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24718"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00538.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:41:53Z","timestamp":1761054113000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00538.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10,1]]}},"alternative-id":["10.1152\/ajpcell.00538.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00538.2025","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]},"assertion":[{"value":"2025-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-16","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}