{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:08:18Z","timestamp":1789538898928,"version":"build-2803163510"},"reference-count":40,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000052","name":"HHS | NIH | NIH Office of the Director","doi-asserted-by":"publisher","award":["1S10OD032271"],"award-info":[{"award-number":["1S10OD032271"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["K99CA276891"],"award-info":[{"award-number":["K99CA276891"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["U01CA272977"],"award-info":[{"award-number":["U01CA272977"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA246809"],"award-info":[{"award-number":["R01CA246809"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["F31CA278490"],"award-info":[{"award-number":["F31CA278490"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:p>Despite being an immune-driven condition, our understanding of skeletal muscle and adipose tissue immune cells with cachexia is limited. Here, we identified immune cell populations in tumors, skeletal muscle, and adipose tissue in C26 tumor-bearing mice with\/without 5-fluorouracil (5FU). C26 and C26 + 5FU had increased skeletal muscle profibrotic macrophages, but 5FU reduced inflammatory myeloid cells without sparing mass. Tumor presence and chemotherapy have contrasting effects on certain immune cells, which appeared not necessary for wasting.<\/jats:p>","DOI":"10.1152\/ajpcell.00548.2023","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T04:44:16Z","timestamp":1704689056000},"page":"C606-C621","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["The complex heterogeneity of immune cell signatures across wasting tissues with C26 and 5-fluorouracil-induced cachexia"],"prefix":"10.1152","volume":"326","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4535-0544","authenticated-orcid":false,"given":"Brandon N.","family":"VanderVeen","sequence":"first","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"Cardaci","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0923-9950","authenticated-orcid":false,"given":"Brooke M.","family":"Bullard","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander R.","family":"Huss","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1894-3272","authenticated-orcid":false,"given":"Sierra J.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed D.","family":"Muhammed","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason L.","family":"Kubinak","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daping","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4803-5822","authenticated-orcid":false,"given":"E. Angela","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/rco2.56"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2008.06.013"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/168407"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00624-w"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.04.017"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302895"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/cells11121893"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.01037"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2200064"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/rco2.50"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00325.2022"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2022.2108306"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.593468"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3390\/ph14050478"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12360"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002166"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2022.114029"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198916040-00002"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3791\/54893"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/nu15010102"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13391"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1802611115"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12539"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2018.00526"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205467"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.073965"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.150"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-016-0167-7"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126374"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1186\/s13395-019-0209-y"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2209976119"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000451"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-023-00644-6"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12450"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202200460R"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00472"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15040-1"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.09.009"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00778.2005"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1172\/JCI68523"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00548.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T10:45:38Z","timestamp":1718621138000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00548.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,1]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2,1]]}},"alternative-id":["10.1152\/ajpcell.00548.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00548.2023","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,1]]},"assertion":[{"value":"2023-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-23","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}