{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:55:48Z","timestamp":1785412548593,"version":"3.56.0"},"reference-count":42,"publisher":"American Physiological Society","issue":"6","funder":[{"name":"the National Nature Science Foundation of China","award":["82071655"],"award-info":[{"award-number":["82071655"]}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:p>There is a strong correlation between the reduced expression of ITGA3 in villous tissues and RSA. ITGA3 facilitates the expression of ULK1, thereby promoting autophagy formation and elevating autophagy levels in trophoblast cells. Consequently, this enhances the invasion and migration abilities of trophoblast cells.<\/jats:p>","DOI":"10.1152\/ajpcell.00563.2024","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T17:51:02Z","timestamp":1729619462000},"page":"C1941-C1956","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["ITGA3 participates in the pathogenesis of recurrent spontaneous abortion by downregulating ULK1-mediated autophagy to inhibiting trophoblast function"],"prefix":"10.1152","volume":"328","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1235-3080","authenticated-orcid":false,"given":"Ruiqi","family":"Wang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03ekhbz91","id-type":"ROR","asserted-by":"publisher"}],"name":"Renmin Hospital of Wuhan University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Dai","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03ekhbz91","id-type":"ROR","asserted-by":"publisher"}],"name":"Renmin Hospital of Wuhan University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Deng","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03ekhbz91","id-type":"ROR","asserted-by":"publisher"}],"name":"Renmin Hospital of Wuhan University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lujia","family":"Tang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03ekhbz91","id-type":"ROR","asserted-by":"publisher"}],"name":"Renmin Hospital of Wuhan University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Liu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03ekhbz91","id-type":"ROR","asserted-by":"publisher"}],"name":"Renmin Hospital of Wuhan University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangbin","family":"Xia","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03ekhbz91","id-type":"ROR","asserted-by":"publisher"}],"name":"Renmin Hospital of Wuhan University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9218-5246","authenticated-orcid":false,"given":"Yanxiang","family":"Cheng","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03ekhbz91","id-type":"ROR","asserted-by":"publisher"}],"name":"Renmin Hospital of Wuhan University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00228-z"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoy004"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000001033"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaaa021"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8983494"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0038-z"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.01.004"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-023-00918-0"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S201675"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e23163"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3233\/CBM-182000"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9181941"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-024-12314-6"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c11734"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-01171-6"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.10.026"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1126\/science.1154822"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.12.044"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30408"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2023.107806"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092342"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20170021"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2017.1422851"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2016.11.027"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201503075"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2022.13391"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35732-6"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2152"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-2438"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.68335"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.22"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2022.103666"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1242\/dev.162305"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1177\/1933719117746766"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3390\/cells8111369"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001604R"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-1138-4"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02334"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117735"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2016.03.030"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C114.627778"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2023.11.013"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00563.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T12:18:13Z","timestamp":1749644293000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00563.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,1]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6,1]]}},"alternative-id":["10.1152\/ajpcell.00563.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00563.2024","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,1]]},"assertion":[{"value":"2024-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-04","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}