{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:49:41Z","timestamp":1790732981140,"version":"4.1.0"},"reference-count":58,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174204"],"award-info":[{"award-number":["82174204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873120"],"award-info":[{"award-number":["81873120"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:p> This study demonstrated for the first time that paeoniflorin (PA) exerts protective effects in diabetic cardiomyopathy mice by alleviating myocardial damage, resisting ferroptosis, and changing the community composition and structure of the intestinal microbiota, and 11,12-epoxyeicosatrienoic acid (11,12-EET) may serve as a key contributor in its therapeutic efficacy. <\/jats:p>","DOI":"10.1152\/ajpcell.00565.2023","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T09:38:38Z","timestamp":1705311518000},"page":"C724-C741","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":39,"title":["Paeoniflorin confers ferroptosis resistance by regulating the gut microbiota and its metabolites in diabetic cardiomyopathy"],"prefix":"10.1152","volume":"326","author":[{"given":"Haowei","family":"Wu","sequence":"first","affiliation":[{"name":"School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiedong","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songqing","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Hao","sequence":"additional","affiliation":[{"name":"School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuoquan","family":"Zhong","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Wenzhou Medical University, Wenzhou, Zhejiang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7213-8942","authenticated-orcid":false,"given":"Jufang","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhuji People\u2019s Hospital, Shaoxing, Zhejiang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangyuan","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.314665"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01553-4"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.314607"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-311448"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.10.005"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.940663"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7807"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175782"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1039\/d3fo01684f"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-007-7240-x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S90030"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1072007"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5647219"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2022.113429"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116567"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6093216"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109754"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153345"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.120.008220"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.132747"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.808480"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106367"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-022-00735-4"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-015-1483-5"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.907757"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2023.2225543"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202206007"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.08.009"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3159717"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2018.01009"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115253"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1093\/jpp\/rgad047"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4358"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-016-0222-x"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12155"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-9-123"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.990476"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1169843"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-022-01271-6"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-329996"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-021-00880-5"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0495-2"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1089991"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2021.12.004"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1014577"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13807"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.10.270"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.69.1.145"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2014.10.008"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1126\/science.6301011"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/nature12175"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1981.tb11000.x"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000088"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508081102"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1080\/03602532.2022.2051045"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2021.03.010"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00565.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T14:45:42Z","timestamp":1718635542000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00565.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3,1]]}},"alternative-id":["10.1152\/ajpcell.00565.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00565.2023","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,1]]},"assertion":[{"value":"2023-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-19","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}