{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:40:40Z","timestamp":1773308440765,"version":"3.50.1"},"reference-count":32,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2002,9,1]]},"abstract":"<jats:p> We found that isolated guinea pig spinal cord white matter is resistant to acute oxygen-glucose deprivation. Sixty minutes of oxygen-glucose deprivation resulted in a 60% reduction of compound action potential (CAP) conductance, and there was a near complete recovery after 60 min reperfusion. Corresponding horseradish peroxidase-exclusion assay showed little axonal membrane damage. To further deprive the axons of metabolic substrate, we added 2 mM sodium cyanide or 2 mM sodium azide, both mitochondrial suppressors, to the ischemic medium, which completely abolished CAP and resulted in a 15 to \u223c30% recovery postreperfusion. Both compounds preferentially reduced the conductance of large diameter axons. We suggest the residual ATP in our ischemic model can protect anatomic integrity and physiological functioning of spinal axons following ischemic insult. This further suggests that oxygen-glucose deprivation alone cannot be solely responsible for short-term functional and anatomic damage. The damaging effects of ischemia in vivo may be mediated by factors originating from the gray matter of the cord or other systemic factors; both were largely eliminated in our in vitro white matter preparation. <\/jats:p>","DOI":"10.1152\/ajpcell.00591.2001","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T00:10:14Z","timestamp":1368490214000},"page":"C980-C989","source":"Crossref","is-referenced-by-count":18,"title":["Resistance of isolated mammalian spinal cord  white matter to oxygen-glucose deprivation"],"prefix":"10.1152","volume":"283","author":[{"given":"Melissa A.","family":"Peasley","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Center for Paralysis Research, Purdue University, West Lafayette, Indiana 47907"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riyi","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Center for Paralysis Research, Purdue University, West Lafayette, Indiana 47907"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-03-00840.1992"},{"key":"B3","first-page":"993","volume":"12","author":"Asano T","year":"1995","journal-title":"J Neurotrauma"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(83)90150-1"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(86)90025-4"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90162-6"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(96)01029-6"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(94)90015-9"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1985.65.1.101"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.12.2532"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(00)00430-9"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.78.4.2095"},{"key":"B15","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1161\/01.STR.21.1.52","volume":"21","author":"Ransom BR","year":"1990","journal-title":"Stroke"},{"key":"B16","first-page":"121","volume":"71","author":"Ransom BR","year":"1993","journal-title":"Res Publ Assoc Res Nerv Ment Dis"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-10-03554.1998"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410190202"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(98)00781-4"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1976.45.6.0638"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.4.529"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.4.1763"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.76.3.1572"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.81.5.2406"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00096-8"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00596-6"},{"key":"B27","first-page":"1130","volume":"18","author":"Shi R","year":"2001","journal-title":"J Neurotrauma"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199801000-00002"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199802160-00017"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00230-3"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.11.4212"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb44808.x"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300309"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(00)00386-5"},{"key":"B36","first-page":"191","volume":"71","author":"Young W.","year":"1993","journal-title":"Res Publ Assoc Res Nerv Ment Dis"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00591.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T19:13:52Z","timestamp":1718651632000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00591.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9,1]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,9,1]]}},"alternative-id":["10.1152\/ajpcell.00591.2001"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00591.2001","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9,1]]}}}