{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:09:53Z","timestamp":1792480193285,"version":"4.5.0"},"reference-count":219,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01EB024556"],"award-info":[{"award-number":["R01EB024556"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:p>The foreign body response (FBR) is an inevitable host response to implanted materials, initiated by tissue injury and marked by a cascade of inflammatory and fibrotic processes. Following implantation, local tissue damage triggers acute inflammation, characterized by immune cell recruitment and activation. Over time, this response advances to a chronic fibrotic phase marked by dense extracellular matrix deposition and fibrous capsule formation, which can encapsulate and, in some cases, functionally isolate the implant. Both the early inflammatory and late fibrotic stages of FBR can severely impair the performance and longevity of implants. FBR is governed by a dynamic and multifaceted network of molecular signaling pathways, cellular mechanosensing mechanisms, and intercellular communication. Despite its clinical significance, the molecular underpinnings of FBR remain incompletely defined. A deeper molecular understanding is critical for the rational design of next-generation biomaterials that mitigate adverse host responses and improve biocompatibility. In this review, we provide the first comprehensive overview of the current knowledge of the molecular events driving FBR, with the goal of informing strategies for therapeutic modulation and biomaterial innovation.<\/jats:p>","DOI":"10.1152\/ajpcell.00595.2025","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T14:32:24Z","timestamp":1758551544000},"page":"C1468-C1486","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Molecular signaling in biomaterial-induced foreign body response: current perspectives"],"prefix":"10.1152","volume":"329","author":[{"given":"Suneha G.","family":"Rahaman","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/047s2c258","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Maryland","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3428-4462","authenticated-orcid":false,"given":"Mohammad I.","family":"Khan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/047s2c258","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Maryland","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karunakaran R.","family":"Sankaran","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/047s2c258","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Maryland","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6481-392X","authenticated-orcid":false,"given":"Shaik O.","family":"Rahaman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/047s2c258","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Maryland","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbw006"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001193"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2017.05.001"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.11.004"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071794"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35958"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1320"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4290"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.aax7043"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2025.1668930"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2017.38.4052"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001682"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2544"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.108"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/cm.20041"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1126\/science.1116995"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2005.11.1"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V55.1.156.156"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.07.027"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2013.1601"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(20000315)49:4<435::AID-JBM2>3.0.CO;2-Y"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31658"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065x.2000.17706.x"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0605289"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/bit.24559"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.06.034"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801451"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132557"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00123"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201903188R"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.04.021"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abd4077"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2019.04.016"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.014597"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb8471"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.09.024"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34104"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4094"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3904"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2019.08.010"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.8b00444"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.570195"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.02.015"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.008"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.02.034"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.12703\/P6-13"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.08.011"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1002\/path.5632"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1008588"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171491"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4866"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.94.07122212"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E11-05-0393"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/nri2990"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399411001943"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2014.06.041"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122855"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00187.2016"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.712380"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1172\/JCI75331"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202407531"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1411872"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEB.2023.0300"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100783"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2022.0066"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E20-08-0536"},{"key":"B68","first-page":"56","volume":"146","author":"Desmouliere A","year":"1995","journal-title":"Am J Pathol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2011.08.004"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107575"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2019.03.027"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00722-z"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.9.2730"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e02-11-0729"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200506179"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064560"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130386"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.85.12.1173"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-020712-163930"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1039\/C3BM60319A"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.03.027"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.02.003"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29167-2"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-77377-8_5"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00054.2019"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00260.2018"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1002\/term.3229"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12532"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312837"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1186\/s40169-015-0047-4"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E17-04-0228"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2018.0229"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2597"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2612-2"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3960"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3390\/cells10051000"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(02)00971-6"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.921626"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.02.050"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.01.007"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03481-6"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-070918-050509"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-019-00584-5"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23482-5"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201808050"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.689397"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202300222R"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.608951"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8525"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3336"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1038\/nature10137"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.3390\/cells10123506"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.REV119.007963"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29678"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12502"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7333"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902818106"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.10.008"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2023.05.001"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101150"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00300.2014"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030663"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-020-0775-5"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.adc9656"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00739-4"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1515\/ntrev-2020-0076"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.10537"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b01326"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-98161-1"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-98161-1_1"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0306164"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2012.01146.x"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-98161-1_11"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02229-4"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201800675"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1016\/s0955-0674(02)00368-x"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-005-5134-3"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00036.2018"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00531-5"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02024-9"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27103126"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202102852"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190103"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1038\/nature10152"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0118"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1038\/nature21035"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.11.037"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aao4881"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20130091"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014003"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1126\/stke.2922005cm6"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.1159665"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200209)32:9<2653::AID-IMMU2653>3.0.CO;2-V"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30313"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.6.1061"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.13.8.823"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(19971215)37:4<481::AID-JBM6>3.0.CO;2-H"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9440(10)61717-8"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63265-8"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.037200"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200012)30:12<3585::AID-IMMU3585>3.0.CO;2-Y"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-006-0697-9"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.4161\/jkst.24777"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201111116"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201701424R"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050645"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070401"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1575"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.02945.x"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200212031"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-221598"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0107058"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.03.039"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-384289"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113506"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.07.027"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1038\/nri1418"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.4161\/cib.3.3.11456"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13640"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2013.02.003"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000500"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.12.039"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.061213"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1007-1110"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2005.11.002"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2957"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21186629"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-021-03875-x"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E19-01-0009"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)81559-7"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E19-12-0707"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30375"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25282"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.01.045"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2009.02.002"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1023\/b:jmsm.0000021094.50889.5c"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.002"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2008.04.004"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00037.2011"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-260323"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12608"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102477"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.02.036"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.162124199"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.07.010"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31221"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2011.06.013"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.01.074"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35757"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32609"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1021\/bm200248h"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2014.09.006"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.37582"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1038\/srep33277"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.05.051"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.05.002"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.3390\/ma14237372"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-013-5075-2"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1039\/d1bm00746g"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67056-9"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00595.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:28:51Z","timestamp":1763749731000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00595.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,1]]},"references-count":219,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11,1]]}},"alternative-id":["10.1152\/ajpcell.00595.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00595.2025","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,1]]},"assertion":[{"value":"2025-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-05","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}