{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:28:59Z","timestamp":1789187339207,"version":"build-2803163510"},"reference-count":108,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["PGS-D"],"award-info":[{"award-number":["PGS-D"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015007","name":"NSERC | RES'EAU-WaterNET","doi-asserted-by":"publisher","award":["PGS-D"],"award-info":[{"award-number":["PGS-D"]}],"id":[{"id":"10.13039\/501100015007","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015007","name":"NSERC | RES'EAU-WaterNET","doi-asserted-by":"publisher","award":["RGPIN-2017-03904"],"award-info":[{"award-number":["RGPIN-2017-03904"]}],"id":[{"id":"10.13039\/501100015007","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015007","name":"NSERC | RES'EAU-WaterNET","doi-asserted-by":"publisher","award":["RGPIN-2018-06781"],"award-info":[{"award-number":["RGPIN-2018-06781"]}],"id":[{"id":"10.13039\/501100015007","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>BACE1 cleavage of APP generates amyloid-\u03b2, overproduction of which perturbs physiological function in the brain. The neurotrophic factor BDNF reduces BACE1 cleavage of APP, potentially reducing amyloid-\u03b2 production in the brain. Here, we show that this may be the result of BDNF altering the subcellular distribution of BACE1, reducing localization to acidic compartments where enzymatic activity is increased. This effect is independent of clathrin-mediated endocytosis, as BACE1 cleavage of APP is unchanged by PitStop2 treatment.<\/jats:p>","DOI":"10.1152\/ajpcell.00642.2025","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T17:20:28Z","timestamp":1774286428000},"page":"C1296-C1308","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["BDNF alters \u03b2-cleavage of APP and subcellular distribution of BACE1"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6314-375X","authenticated-orcid":false,"given":"Ryan D.","family":"Hallam","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/056am2717","id-type":"ROR","asserted-by":"publisher"}],"name":"Brock University","place":["Canada"]},{"id":[{"id":"https:\/\/ror.org\/056am2717","id-type":"ROR","asserted-by":"publisher"}],"name":"Brock University","place":["Canada"]},{"name":"University of Western Ontario","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2002-1706","authenticated-orcid":false,"given":"Gregory","family":"Foran","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/056am2717","id-type":"ROR","asserted-by":"publisher"}],"name":"Brock University","place":["Canada"]},{"id":[{"id":"https:\/\/ror.org\/056am2717","id-type":"ROR","asserted-by":"publisher"}],"name":"Brock University","place":["Canada"]},{"name":"Baylor College of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha K.","family":"Fletcher","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/056am2717","id-type":"ROR","asserted-by":"publisher"}],"name":"Brock University","place":["Canada"]},{"id":[{"id":"https:\/\/ror.org\/056am2717","id-type":"ROR","asserted-by":"publisher"}],"name":"Brock University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1577-2658","authenticated-orcid":false,"given":"Rebecca E. K.","family":"MacPherson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/056am2717","id-type":"ROR","asserted-by":"publisher"}],"name":"Brock University","place":["Canada"]},{"name":"Brock University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7080-2859","authenticated-orcid":false,"given":"Aleksandar","family":"Necakov","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/056am2717","id-type":"ROR","asserted-by":"publisher"}],"name":"Brock University","place":["Canada"]},{"id":[{"id":"https:\/\/ror.org\/056am2717","id-type":"ROR","asserted-by":"publisher"}],"name":"Brock University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2017-0063"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-4-3"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1781"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00030"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-019-0447-2"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2121-6-30"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603838103"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2017.05.005"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)53650-4"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.11.6186"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.6.2419"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m304009200"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161445"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24900-4"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1698-21.2021"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b05891"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02185-07"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200207113"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.01.040"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2010.00008"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt194"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1201-14.2014"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.020"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx057"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.005222"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13430"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abn9380"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-240146"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/nature19323"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-220046"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.11703"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.06.019"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-019-0333-5"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00299.2015"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0496-05.2005"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.10.028"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072796"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2016.11.014"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2016.63"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14084"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00114.2023"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.3.498"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.061002998"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-171150"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.02.013"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2019-0910"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.02.001.2010"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2015.56342"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2004.03.002"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0537-4"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2009.048512"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.09.008"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002242"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00418.2021"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90273-3"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1561"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/s0169-328x(00)00023-1"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4736-08.2009"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145710001008"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000091890.32140.8f"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3233\/jad-2005-8305"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.09.004"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2391"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.04.032"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.03.016"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.665867"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.70001"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay7794"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E11-11-0944"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.12.014"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2003.00135.x"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106611"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.2006.01706.x"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-025-02595-5"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200301115"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.04.036"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136950"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.08.024"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X19666210121163224"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.13.6075"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.3086"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201947954"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045799"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3960-09.2009"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806133105"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14034"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-00863-8"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1152-3"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt211"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1172\/JCI65401"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100745108"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1242\/bio.20147955"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2021-0330"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-8-S1-P10"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2371-12.2013"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.10.018"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2689"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025097"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.219675"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503689102"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2272-11.2012"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0206-16.2016"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3882-05.2006"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072164"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90320-8"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.10.7410"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313893200"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00642.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:44:22Z","timestamp":1780325062000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00642.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":108,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"alternative-id":["10.1152\/ajpcell.00642.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00642.2025","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]},"assertion":[{"value":"2025-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-27","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}