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Carver Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2025,2,1]]},"abstract":"<jats:p>\n                    Pulmonary ionocytes express high levels of cystic fibrosis transmembrane conductance regulator (CFTR) channels. When studied using the short-circuit current technique, ionocytes produce CFTR-dependent short-circuit currents consistent with Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    secretion. However, when studied without a voltage clamp, data indicate that ionocytes absorb Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    . In this review, we resolve these seemingly conflicting findings by considering the different transepithelial voltages and the resultant movement of Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    during short circuit and physiological open-circuit conditions. This analysis indicates that behavior under short-circuit conditions cannot be directly extrapolated to infer behavior under physiologic conditions. Finally, we discuss the potential role of basolateral Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    channels in controlling absorption and secretion in ionocytes.\n                  <\/jats:p>","DOI":"10.1152\/ajpcell.00672.2024","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T02:40:31Z","timestamp":1735008031000},"page":"C400-C403","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Do pulmonary ionocytes absorb chloride or secrete chloride?"],"prefix":"10.1152","volume":"328","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5535-2925","authenticated-orcid":false,"given":"Ian M.","family":"Thornell","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/036jqmy94","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Iowa","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Lei","sequence":"additional","affiliation":[{"name":"University of Iowa","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Paul B.","family":"McCray","sequence":"additional","affiliation":[{"name":"University of Iowa","place":["United States"]},{"name":"University of Iowa","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1646-6206","authenticated-orcid":false,"given":"Michael J.","family":"Welsh","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/036jqmy94","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Iowa","place":["United States"]},{"name":"University of Iowa","place":["United States"]},{"name":"University of Iowa","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0394-6"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0393-7"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-042420-094031"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2022-0280OC"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06549-9"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI171268"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202309-1565OC"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2022-0241OC"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202205-1010LE"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.1.S23"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199610000-00002"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1979.236.1.F1"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1994.267.4.C1136"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/301421a0"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2011.00006"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1951.tb00800.x"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.18.6167"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.117.5.423"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4546"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00672.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T11:49:38Z","timestamp":1743594578000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00672.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,1]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2,1]]}},"alternative-id":["10.1152\/ajpcell.00672.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00672.2024","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,1]]},"assertion":[{"value":"2024-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-13","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}