{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:52:37Z","timestamp":1792601557480,"version":"4.5.0"},"reference-count":35,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS131322"],"award-info":[{"award-number":["R01NS131322"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS112381"],"award-info":[{"award-number":["R01NS112381"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["S10OD030335"],"award-info":[{"award-number":["S10OD030335"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:p>Mitochondrial complex I is a key enzyme of mammalian oxidative phosphorylation. Here, we provide the first quantitative map of mitochondrial complex I maturation in postnatal mouse tissues. Complex I content rises after birth with striking tissue- and sex-specific patterns, including a dramatic 16-fold increase in kidney. These findings establish a baseline for developmental bioenergetics and a reference for evaluating genetic or disease-related mitochondrial dysfunction.<\/jats:p>","DOI":"10.1152\/ajpcell.00692.2025","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:21:28Z","timestamp":1760660488000},"page":"C1666-C1671","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Postnatal developmental dynamics of mitochondrial complex I in mouse tissues"],"prefix":"10.1152","volume":"329","author":[{"given":"Max","family":"Siragusa","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02r109517","id-type":"ROR","asserted-by":"publisher"}],"name":"Weill Cornell Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7276-278X","authenticated-orcid":false,"given":"Belem","family":"Yoval-S\u00e1nchez","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02r109517","id-type":"ROR","asserted-by":"publisher"}],"name":"Weill Cornell Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Guerrero","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02r109517","id-type":"ROR","asserted-by":"publisher"}],"name":"Weill Cornell Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8469-2283","authenticated-orcid":false,"given":"Alexander","family":"Galkin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02r109517","id-type":"ROR","asserted-by":"publisher"}],"name":"Weill Cornell Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-5793(99)00575-x"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2006.10.001"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.438945"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1023\/a:1010257630935"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520080305"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1042\/bj3110105"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/s0925-4439(96)00072-5"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.21.12753"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1557638"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/s0005-2728(02)00270-0"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1012478"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1159\/000112126"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/s0005-2728(05)80109-4"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101204"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2022.114646"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2008.01.006"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(73)90304-1"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01555-x"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1996.271.5.H2183"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.189670"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.12.002"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.09.029"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-10-21"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9974"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1976.tb00323.x"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1913"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1515\/hmbci-2013-0026"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2024.149494"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mcb.2019.12.008"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.09.035"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160485"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-01584-y"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00819"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02103-8"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1186\/s40170-015-0138-0"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00692.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:29:30Z","timestamp":1763749770000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00692.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,1]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11,1]]}},"alternative-id":["10.1152\/ajpcell.00692.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00692.2025","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,1]]},"assertion":[{"value":"2025-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-29","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}