{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:22:52Z","timestamp":1790230972419,"version":"4.1.0"},"reference-count":51,"publisher":"American Physiological Society","issue":"3","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271721"],"award-info":[{"award-number":["82271721"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071679"],"award-info":[{"award-number":["82071679"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"MOST | National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2705900"],"award-info":[{"award-number":["2023YFC2705900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Center for Big Data and population health of IHM","award":["JKS2022010"],"award-info":[{"award-number":["JKS2022010"]}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271727"],"award-info":[{"award-number":["82271727"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:p>Expression of PFKFB3, a key enzyme in glycolysis, was significantly upregulated both in the mUSMCs and myometrium of mice during late pregnancy after lipopolysaccharide stimulation. Activation of the PI3K-Akt-mTOR pathway enhanced PFKFB3 expression, which is involved in the initiation of glycolysis. Inflammation-activated PFKFB3 via the PI3K-Akt-mTOR pathway, which enhances the cellular glycolytic process and thus promotes myometrium contraction in pregnancy.<\/jats:p>","DOI":"10.1152\/ajpcell.00704.2024","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T10:59:56Z","timestamp":1738753196000},"page":"C895-C907","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Inflammation-induced PFKFB3-mediated glycolysis promoting myometrium contraction through the PI3K-Akt-mTOR pathway in preterm birth mice"],"prefix":"10.1152","volume":"328","author":[{"given":"Jing","family":"He","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03t1yn780","id-type":"ROR","asserted-by":"publisher"}],"name":"The First Affiliated Hospital of Anhui Medical University","place":["People\u2019s Republic of China"]},{"name":"Anhui Medical University","place":["People\u2019s Republic of China"]},{"name":"Anqing Medical Center of Anhui Medical University","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Li","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03t1yn780","id-type":"ROR","asserted-by":"publisher"}],"name":"The First Affiliated Hospital of Anhui Medical University","place":["People\u2019s Republic of China"]},{"name":"Anhui Medical University","place":["People\u2019s Republic of China"]},{"name":"Anhui Province Key Laboratory of Reproductive Disorders and Obstetrics and Gynaecology Diseases","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Yu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03t1yn780","id-type":"ROR","asserted-by":"publisher"}],"name":"The First Affiliated Hospital of Anhui Medical University","place":["People\u2019s Republic of China"]},{"name":"Anhui Medical University","place":["People\u2019s Republic of China"]},{"name":"Anhui Province Key Laboratory of Reproductive Disorders and Obstetrics and Gynaecology Diseases","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyi","family":"Xu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03t1yn780","id-type":"ROR","asserted-by":"publisher"}],"name":"The First Affiliated Hospital of Anhui Medical University","place":["People\u2019s Republic of China"]},{"name":"Ministry of Education","place":["People\u2019s Republic of China"]},{"name":"Ministry of Education of the People\u2019s Republic of China","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixian","family":"Tian","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03t1yn780","id-type":"ROR","asserted-by":"publisher"}],"name":"The First Affiliated Hospital of Anhui Medical University","place":["People\u2019s Republic of China"]},{"name":"Ministry of Education","place":["People\u2019s Republic of China"]},{"name":"Ministry of Education of the People\u2019s Republic of China","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8125-3525","authenticated-orcid":false,"given":"Ping","family":"Zhou","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03t1yn780","id-type":"ROR","asserted-by":"publisher"}],"name":"The First Affiliated Hospital of Anhui Medical University","place":["People\u2019s Republic of China"]},{"name":"Anhui Medical University","place":["People\u2019s Republic of China"]},{"name":"Anhui Province Key Laboratory of Reproductive Disorders and Obstetrics and Gynaecology Diseases","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5968-6332","authenticated-orcid":false,"given":"Zongzhi","family":"Yin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03t1yn780","id-type":"ROR","asserted-by":"publisher"}],"name":"The First Affiliated Hospital of Anhui Medical University","place":["People\u2019s Republic of China"]},{"name":"Anhui Medical University","place":["People\u2019s Republic of China"]},{"name":"Anhui Province Key Laboratory of Reproductive Disorders and Obstetrics and Gynaecology Diseases","place":["People\u2019s Republic of China"]},{"name":"Center for Big Data and Population Health of IHM","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(23)00878-4"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/children10050907"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1177\/1933719112446084"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-16-0157"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.660983"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2006.05.001"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.040"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-020-00807-y"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2020.12.004"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fgwh.2021.777643"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0450-2"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/FM9.0000000000000199"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.09.011"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.14794"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2022.03.004"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2021.188559"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-023-00887-x"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2021.03.019"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.06.037"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.03.008"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201812-2290OC"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202300900R"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2024.149958"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2019.02.007"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.966067"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.0783p.x"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(90)90707-r"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/0301-2115(95)02195-d"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.101.17.2090"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.68.2.466"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00598.2023"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01827-6"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-022-04587-x"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115455"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2016.03.005"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2023.01.007"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-023-02959-w"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-023-03664-4"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2023.102643"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-020-0404-9"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13195"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2023.2191217"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.103043"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1172\/jci150595"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154419"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24098391"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032652"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.11938"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e17551"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2020.02.027"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04167-7"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00704.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T16:00:31Z","timestamp":1744300831000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00704.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,1]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3,1]]}},"alternative-id":["10.1152\/ajpcell.00704.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00704.2024","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,1]]},"assertion":[{"value":"2024-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}