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Notably, male Nherf2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice exhibit impaired glucose tolerance and insulin responsiveness, yet neither sex shows further worsening with diet challenge. In addition, elevated hepatic Cyp7a1 levels were observed in Nherf2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice, but there was reduced cholesterol absorption in the ileum, along with enlarged gallbladders and diminished ileal bile acid content, highlighting significant metabolic alterations linked to Nherf2 deficiency.\n                  <\/jats:p>","DOI":"10.1152\/ajpcell.00716.2025","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:00:16Z","timestamp":1761919216000},"page":"C1765-C1774","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Nherf2\u00a0is a major determinant of bile acid pool dynamics and contributes to regulation of Western diet-induced 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