{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T13:13:24Z","timestamp":1793798004000,"version":"4.6.1"},"reference-count":67,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100000069","name":"HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR075794-01A1\/AR\/NIAMS (NPG)"],"award-info":[{"award-number":["R01AR075794-01A1\/AR\/NIAMS (NPG)"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008231","name":"Arkansas Biosciences Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008231","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM125503"],"award-info":[{"award-number":["P20GM125503"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>Using multi-omics integration, we establish that DNA methylation status likely influences the muscle transcriptome during cancer cachexia, affecting pathways commonly disrupted in cachexia including those associated with neurodegeneration and metabolism. Epigenetic dysregulation occurs early and progresses during the onset and establishment of cancer cachexia, highlighting DNA methylation as a potential therapeutic target to slow or mitigate disease progression.<\/jats:p>","DOI":"10.1152\/ajpcell.00751.2025","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T18:41:06Z","timestamp":1765564866000},"page":"C294-C312","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Skeletal muscle methylome-transcriptome disruptions during the onset and progression of colorectal cancer-induced cachexia"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9811-3585","authenticated-orcid":false,"given":"Ana Regina","family":"Cabrera","sequence":"first","affiliation":[{"name":"University of Arkansas","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Ronald G.","family":"Jones","sequence":"additional","affiliation":[{"name":"University of Arkansas","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor R.","family":"Shrems","sequence":"additional","affiliation":[{"name":"University of Arkansas","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5019-2125","authenticated-orcid":false,"given":"Francielly","family":"Morena","sequence":"additional","affiliation":[{"name":"University of Arkansas","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3210-1629","authenticated-orcid":false,"given":"Yuan","family":"Wen","sequence":"additional","affiliation":[{"name":"University of Kentucky","place":["United States"]},{"name":"University of Kentucky","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1919-5907","authenticated-orcid":false,"given":"Tyrone A.","family":"Washington","sequence":"additional","affiliation":[{"name":"University of Arkansas","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2783-7137","authenticated-orcid":false,"given":"Kevin A.","family":"Murach","sequence":"additional","affiliation":[{"name":"University of Arkansas","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9621-2005","authenticated-orcid":false,"given":"Nicholas P.","family":"Greene","sequence":"additional","affiliation":[{"name":"University of Arkansas","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32055"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.764912"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2022.11.001"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.105"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12220"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-013-1894-4"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12232"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00660.2021"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00196.2023"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12998"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008564"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2021.10.010"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12321"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.10.017"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-024-00618-1"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1264"},{"key":"B19","first-page":"631","volume":"10","author":"Turek-Plewa J","year":"2005","journal-title":"Cell Mol Biol Lett"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1113\/EP088894"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00061.2018"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3390\/nu15214570"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4197"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2012-13-10-r87"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq650"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.150"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/s44319-024-00299-z"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1113\/JP286681"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1093\/function\/zqad062"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024650"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-023-09462-7"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s44324-024-00038-x"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01648"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1242\/dev.202556"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.40463"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-025-00619-0"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010075"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-025-02067-z"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00647.2024"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2024.108233"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw005"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12315"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022538"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00039.2012"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101498"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-021-01188-1"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1203"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174409990171"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10061372"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2014.10.012"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-024-00555-5"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72730-z"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1002\/ntls.20220021"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay9592"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1172\/JCI128411"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1172\/JCI68523"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2022.911020"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054613"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa034"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1318305"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005457"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.09.009"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00497.2024"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00017.2007"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.923190"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114587"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.14.12.8051-8057.1994"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00751.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T15:55:00Z","timestamp":1769183700000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00751.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,1]]}},"alternative-id":["10.1152\/ajpcell.00751.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00751.2025","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,1]]},"assertion":[{"value":"2025-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-23","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}