{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T21:14:41Z","timestamp":1774559681342,"version":"3.50.1"},"reference-count":28,"publisher":"American Physiological Society","issue":"3","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Shanghai Magnolia Talent Plan Pujiang Project","award":["24PJA097"],"award-info":[{"award-number":["24PJA097"]}]},{"name":"Shanghai Sixth People's Hospital Young Talent Development Program","award":["ynqn202413"],"award-info":[{"award-number":["ynqn202413"]}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:p>RAAS inhibitors are routinely withheld during acute kidney injury (AKI) because of concerns about impaired renal perfusion. Contrary to this dogma, we show that telmisartan enhances renal recovery following ischemia-reperfusion injury. Transcriptomic analyses reveal that telmisartan restores fatty acid oxidation and mitochondrial-peroxisomal lipid metabolism, key pathways suppressed in AKI. These findings suggest that selected RAAS inhibitors may actively promote post-AKI metabolic recovery rather than merely pose hemodynamic risk.<\/jats:p>","DOI":"10.1152\/ajpcell.00801.2025","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T22:11:32Z","timestamp":1770329492000},"page":"C695-C705","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The angiotensin II receptor antagonist telmisartan promotes renal recovery after ischemia-reperfusion injury by reprogramming fatty acid metabolism"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2018-4578","authenticated-orcid":false,"given":"Chang","family":"Chu","sequence":"first","affiliation":[{"name":"Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine","place":["People\u2019s Republic of China"]},{"name":"University of Heidelberg","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Deli\u0107","sequence":"additional","affiliation":[{"name":"University of Heidelberg","place":["Germany"]},{"name":"Boehringer Ingelheim Pharma GmbH & Co. KG","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Heidelberg","place":["Germany"]},{"name":"The First Affiliated Hospital of Jinan University","place":["People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shufei","family":"Zeng","sequence":"additional","affiliation":[{"name":"University of Heidelberg","place":["Germany"]},{"name":"Southern Medical University","place":["People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed M. S.","family":"Gaballa","sequence":"additional","affiliation":[{"name":"Academy of Scientific Research and Technology (ASRT), Cairo, Egypt"},{"name":"Benha University","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Klein","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Pharma GmbH & Co. KG","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1195-6871","authenticated-orcid":false,"given":"Saban","family":"Elitok","sequence":"additional","affiliation":[{"name":"Health and Medical University","place":["Germany"]},{"name":"Klinikum Ernst von Bergmann","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl-Friedrich","family":"Hocher","sequence":"additional","affiliation":[{"name":"University of Heidelberg","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1718-2918","authenticated-orcid":false,"given":"Bernhard K.","family":"Kr\u00e4mer","sequence":"additional","affiliation":[{"name":"University of Heidelberg","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"University of Heidelberg","place":["Germany"]},{"name":"Health and Medical University","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8143-0579","authenticated-orcid":false,"given":"Berthold","family":"Hocher","sequence":"additional","affiliation":[{"name":"University of Heidelberg","place":["Germany"]},{"name":"Reproductive and Genetic Hospital of CITIC-Xiangya","place":["People\u2019s Republic of China"]},{"name":"IMD Institut f\u00fcr Medizinische Diagnostik Berlin-Potsdam GbR","place":["Germany"]},{"name":"Central South University","place":["People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-3934-7"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.42"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32563-2"},{"key":"B4","volume-title":"Guyton and Hall Textbook of Medical Physiology","author":"Hall JE","year":"2015"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60647-9"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1159\/000339789"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2018.4749"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005070757"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/01.mnh.0000203190.34643.d4"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000123072.34629.57"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.204"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113357"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/01.asn.0000050760.87113.25"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2007.07.041"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.14103"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00528.2022"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.01.010"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60336-4"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.09.033"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.161783"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.699192"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019050534"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31772-9"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107520"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0892"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00039.2017"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145723"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-1-200907070-00122"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00801.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T20:31:47Z","timestamp":1774557107000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00801.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,1]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,1]]}},"alternative-id":["10.1152\/ajpcell.00801.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00801.2025","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,1]]},"assertion":[{"value":"2025-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-30","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}