{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:39:47Z","timestamp":1791614387519,"version":"4.3.4"},"reference-count":78,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL162773 and R01 HL172944"],"award-info":[{"award-number":["R01 HL162773 and R01 HL172944"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01 BX004249 and IK6 BX006040"],"award-info":[{"award-number":["I01 BX004249 and IK6 BX006040"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["T32 DK11275"],"award-info":[{"award-number":["T32 DK11275"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Iowa Fraternal Order of Eagles Diabetes Research Center","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>\n                    This study combines AI modeling and experimental validation to define key structural features and receptor interactions of the BBSome complex. The analysis identifies BBS1 and BBS9 as central hubs, reveals how the BBS1\n                    <jats:sup>M390R<\/jats:sup>\n                    mutation destabilizes the complex, and uncovers novel contacts with various receptors including those involved in metabolic regulation. These findings provide a predictive framework linking BBSome structure to ciliary signaling and metabolic regulation in Bardet\u2013Biedl syndrome.\n                  <\/jats:p>","DOI":"10.1152\/ajpcell.00804.2025","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T15:01:23Z","timestamp":1774969283000},"page":"C1271-C1285","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Harnessing AlphaFold3 to elucidate BBSome structure and protein partners"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7096-8613","authenticated-orcid":false,"given":"Deng Fu","family":"Guo","sequence":"first","affiliation":[{"name":"University of Iowa Carver College of Medicine","place":["United States"]},{"name":"Iowa City Veterans Affairs Health Care System","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Younes","family":"Rouabhi","sequence":"additional","affiliation":[{"name":"University of Iowa Carver College of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4750-5554","authenticated-orcid":false,"given":"Mallory","family":"Tollefson","sequence":"additional","affiliation":[{"name":"University of Iowa Carver College of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8673-0703","authenticated-orcid":false,"given":"Kai","family":"Vorhies","sequence":"additional","affiliation":[{"name":"University of Iowa Carver College of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5136-6748","authenticated-orcid":false,"given":"Kamal","family":"Rahmouni","sequence":"additional","affiliation":[{"name":"University of Iowa Carver College of Medicine","place":["United States"]},{"name":"Iowa City Veterans Affairs Health Care System","place":["United States"]},{"name":"University of Iowa Carver College of Medicine","place":["United States"]},{"name":"University of Iowa Carver College of Medicine","place":["United States"]},{"name":"University of Iowa Carver College of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-023-00698-5"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-023-00587-9"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-010-0425-4"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.05.015"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23862"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17946"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.03.053"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2013-101785"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/ng1352"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.013905"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3003025"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005890"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005311"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910268107"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2920"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002358"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2101590118"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.168740"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.53910"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.55254"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.53322"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4464"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaf067"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08416-7"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1126\/science.adg7492"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/bioadv\/vbaf093"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad989"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-019-2923-1"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.4478"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/function\/zqad070"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.06.041"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1242\/bio.043786"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1126\/science.adn6354"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt473"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.27434"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.59119"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.55954"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.341487"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708571104"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2019.06.006"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202201050"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21480"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2020.10.006"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1242\/bio.026278"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.09.011"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.09.004"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202111076"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30945"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.11.011"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22001"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1086\/346172"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195005"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03643-9"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1126\/science.1232995"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp031"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2023.03.003"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202003020"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3109\/13816810.2011.567319"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12644"},{"key":"B61","first-page":"482","volume":"23","author":"Ullah A","year":"2017","journal-title":"Mol Vis"},{"key":"B62","first-page":"461","volume":"21","author":"van Huet RA","year":"2015","journal-title":"Mol Vis"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn277"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.79299"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201541432"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2013.08.004"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.9.996"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.87623"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E12-02-0134"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711027105"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-023-02559-9"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3390\/cells12222662"},{"key":"B73","doi-asserted-by":"publisher","unstructured":"Kristyna Maskova HH, Bykova S, Smite S, Prasai A, Rozbesky D, Huranova M. Bardet-Biedl syndrome 1 mutations differentially impact BBSome integrity and its function in ciliary trafficking (Preprint). bioRxiv 1\u201325, 2026. doi:10.64898\/2026.01.23.701255.","DOI":"10.64898\/2026.01.23.701255"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0622-0"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.155900"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2328"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-63988-w"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddaf005"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00804.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:44:26Z","timestamp":1780325066000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00804.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":78,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"alternative-id":["10.1152\/ajpcell.00804.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00804.2025","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]},"assertion":[{"value":"2025-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}