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In this work, we demonstrate that positive allosteric modulation of the GABA\n                    <jats:sub>A<\/jats:sub>\n                    R increases cell survival in vitro and promotes morphological changes associated with maturation. Both effects are generated by an increase in intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    and activation of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -CaM-dependent kinases signaling pathway, which subsequently promote AKT phosphorylation, triggering antiapoptotic signals.\n                  <\/jats:p>","DOI":"10.1152\/ajpcell.00813.2025","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:32:03Z","timestamp":1780075923000},"page":"C41-C58","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Allosteric potentiation of GABA\n                    <sub>A<\/sub>\n                    receptor promotes survival and maturation of oligodendroglial cells in vitro via Ca\n                    <sup>2+<\/sup>\n                    \/CaMK\/AKT signaling 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