{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:23:54Z","timestamp":1793496234221,"version":"4.5.0"},"reference-count":62,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100014989","name":"Chan Zuckerberg Initiative","doi-asserted-by":"publisher","award":["2019-002426"],"award-info":[{"award-number":["2019-002426"]}],"id":[{"id":"10.13039\/100014989","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014989","name":"Chan Zuckerberg Initiative","doi-asserted-by":"publisher","award":["2021-240342"],"award-info":[{"award-number":["2021-240342"]}],"id":[{"id":"10.13039\/100014989","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK","doi-asserted-by":"publisher","award":["22873"],"award-info":[{"award-number":["22873"]}],"id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000697","name":"Rhodes Scholarships","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000697","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UKRI | Medical Research Council","doi-asserted-by":"publisher","award":["Oxford Doctoral Training Partnership"],"award-info":[{"award-number":["Oxford Doctoral Training Partnership"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013373","name":"NIHR | NIHR Oxford Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UKRI | Medical Research Council","doi-asserted-by":"publisher","award":["MR\/V010182\/1"],"award-info":[{"award-number":["MR\/V010182\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pagets Association","award":["PA21010"],"award-info":[{"award-number":["PA21010"]}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>We present the first spatially resolved single-cell atlas of the human Achilles tendon. By sampling across the microanatomy of the tendon from enthesis to muscle, we demonstrate changes in fibroblast composition across this transitional tissue. Distinct fibroblast subsets were discovered with specific transcriptomic signatures, and several were found in distinct spatial locations corresponding to putative functional roles in tendon and adjoining muscle. These findings demonstrate how cellular diversity across a transitional tissue may underlie microanatomical-specific roles.<\/jats:p>","DOI":"10.1152\/ajpcell.00838.2025","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:01:42Z","timestamp":1775062902000},"page":"C1460-C1473","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Fibroblast specialization across microanatomy in a single-cell atlas of human Achilles tendon"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8398-0010","authenticated-orcid":false,"given":"Carla J.","family":"Cohen","sequence":"first","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]},{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4464-242X","authenticated-orcid":false,"given":"Jolet Y.","family":"Mimpen","sequence":"additional","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]},{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4503-7865","authenticated-orcid":false,"given":"Alina","family":"Kurjan","sequence":"additional","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9729-7135","authenticated-orcid":false,"given":"Claudia","family":"Paul","sequence":"additional","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6002-9350","authenticated-orcid":false,"given":"Shreeya","family":"Sharma","sequence":"additional","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Ramos-Mucci","sequence":"additional","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3517-9575","authenticated-orcid":false,"given":"Chinemerem T.","family":"Ikwuanusi","sequence":"additional","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6525-3602","authenticated-orcid":false,"given":"Ali Cenk","family":"Aksu","sequence":"additional","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Boakye Serebour","sequence":"additional","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Nikolic","sequence":"additional","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3899-3872","authenticated-orcid":false,"given":"Kevin","family":"Rue-Albrecht","sequence":"additional","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1378-9173","authenticated-orcid":false,"given":"Christopher","family":"Gibbons","sequence":"additional","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan","family":"Whitwell","sequence":"additional","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Cosker","sequence":"additional","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1323-8646","authenticated-orcid":false,"given":"Steven","family":"Gwilym","sequence":"additional","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5019-2467","authenticated-orcid":false,"given":"Ather","family":"Siddiqi","sequence":"additional","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja Bhaskara","family":"Rajasekaran","sequence":"additional","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet","family":"Branford-White","sequence":"additional","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5288-3077","authenticated-orcid":false,"given":"Adam P.","family":"Cribbs","sequence":"additional","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4994-2264","authenticated-orcid":false,"given":"Philippa A.","family":"Hulley","sequence":"additional","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8960-8335","authenticated-orcid":false,"given":"David","family":"Sims","sequence":"additional","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew J.","family":"Baldwin","sequence":"additional","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J. B.","family":"Snelling","sequence":"additional","affiliation":[{"name":"University of Oxford","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-010-1083-7"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.26060"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1136\/jisakos-2017-000164"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-025-00602-9"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jisako.2023.12.006"},{"key":"B6","volume-title":"Enthesopathies","author":"Alvarez A","year":"2025"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-023-01031-2"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2020.151461"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.11138\/mltj\/2013.3.1.002"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.635561"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12221"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.32098\/mltj.03.2014.12"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03852-1"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05769-3"},{"key":"B15","doi-asserted-by":"publisher","unstructured":"Mimpen JY, Baldwin MJ, Paul C, Ramos-Mucci L, Kurjan A, Cohen CJ, Sharma S, Chevalier Florquin MSN, Hulley PA, McMaster J, Titchener A, Martin A, Costa ML, Gwilym SE, Cribbs AP, Snelling SJB. Exploring cellular changes in ruptured human quadriceps tendons at single-cell resolution (Preprint). bioRxiv, 2024. doi:10.1101\/2024.09.06.611599.","DOI":"10.1101\/2024.09.06.611599"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202300601RRR"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-70786-5"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-220256"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.11.007"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.34133\/2022\/9760390"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.85873"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-023-01613-2"},{"key":"B23","doi-asserted-by":"publisher","unstructured":"Kurjan A, Mimpen JY, Ramos-Mucci L, Aksu AC, Buckley CD, Cribbs AP, Baldwin MJ, Snelling SJB. Cellular and molecular landscapes of human tendons across the lifespan revealed by spatial and single-cell transcriptomics (Preprint). bioRxiv, 2025. doi:10.1101\/2025.06.19.660575.","DOI":"10.1101\/2025.06.19.660575"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00700.2025"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1113\/JP287812"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00372.2020"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.17504\/protocols.io.b2tqqemw"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.17504\/protocols.io.bc6xizfn"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-023-00586-w"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0654-x"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-020-1950-6"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.73600.1"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giaa151"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-021-01206-w"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0619-0"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giy083"},{"key":"B38","doi-asserted-by":"publisher","unstructured":"Blanco-Carmona E. Generating publication ready visualizations for Single Cell transcriptomics using SCpubr (Preprint). bioRxiv, 2022. doi:10.1101\/2022.02.28.482303.","DOI":"10.1101\/2022.02.28.482303"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-021-01033-z"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30755-0"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btab370"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-023-01938-4"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.01.142"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201949499"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-022-00790-8"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.260913"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074930"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2017-098161"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-023-01639-1"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-024-00613-3"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1641570"},{"key":"B54","volume-title":"Achilles Tendon Rupture","author":"Shamrock AG","year":"2025"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.08.020"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03549-5"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01527-9"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/s0945-053x(02)00056-2"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200522263"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-023-00292-7"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/s0945-053x(98)90017-8"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2008.053892"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00838.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:44:34Z","timestamp":1780325074000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00838.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":62,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"alternative-id":["10.1152\/ajpcell.00838.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00838.2025","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]},"assertion":[{"value":"2025-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-03","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}