{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T16:38:26Z","timestamp":1772728706047,"version":"3.50.1"},"reference-count":31,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2022-140774OB-I00"],"award-info":[{"award-number":["PID2022-140774OB-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2023-148439OB-I00"],"award-info":[{"award-number":["PID2023-148439OB-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007509","name":"Sociedad Espa\u00f1ola de Neumolog\u00eda y Cirug\u00eda Tor\u00e1cica","doi-asserted-by":"publisher","award":["1396\/2023"],"award-info":[{"award-number":["1396\/2023"]}],"id":[{"id":"10.13039\/501100007509","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2021SGR00292"],"award-info":[{"award-number":["2021SGR00292"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2021SGR00523"],"award-info":[{"award-number":["2021SGR00523"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"MEC | Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:p>This study presents the oxyslice recording chamber (ORC), a simple and reproducible system for precise oxygen control during brain slice recordings. The ORC has been developed to be easily constructed and implemented in any electrophysiology laboratory. As a proof of concept, we reproduced continuous hypoxia (transient ischemic stroke) and intermittent hypoxia (sleep apnea), revealing distinct and reversible changes in hippocampal function applicable to various hypoxia-related conditions and brain regions.<\/jats:p>","DOI":"10.1152\/ajpcell.00846.2025","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:11:58Z","timestamp":1766020318000},"page":"C356-C364","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Precise dynamic control of tissue oxygenation during brain slice electrophysiology"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9275-3047","authenticated-orcid":false,"given":"Alicia","family":"Jurado","sequence":"first","affiliation":[{"name":"Universitat de Barcelona","place":["Spain"]},{"name":"CIBER de Enfermedades Respiratorias","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna P.","family":"P\u00e9rez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Universitat de Barcelona","place":["Spain"]},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon","family":"Farr\u00e9","sequence":"additional","affiliation":[{"name":"Universitat de Barcelona","place":["Spain"]},{"name":"CIBER de Enfermedades Respiratorias","place":["Spain"]},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Gozal","sequence":"additional","affiliation":[{"name":"Marshall University","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6154-8323","authenticated-orcid":false,"given":"Xavier","family":"Gasull","sequence":"additional","affiliation":[{"name":"Universitat de Barcelona","place":["Spain"]},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1998-9379","authenticated-orcid":false,"given":"Isaac","family":"Almendros","sequence":"additional","affiliation":[{"name":"Universitat de Barcelona","place":["Spain"]},{"name":"CIBER de Enfermedades Respiratorias","place":["Spain"]},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2025.104008"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1186\/2045-8118-10-6"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2016.03.008"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2009.06.005"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fnene.2011.00009"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3791\/61704"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0167-23.2023"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24241"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108557"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039772"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4105-07.2008"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.5665\/SLEEP.1176"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-11-3"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-024-00702-6"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1081345"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2023.1277375"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00024"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.09.045"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1359-18.2018"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2007.00515.x"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00289.2014"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043309"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2010.02.017"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00135"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1039\/c8an02201a"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079220"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1198170"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01803"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00319"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100822RR"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110069"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00846.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T15:36:30Z","timestamp":1772724990000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00846.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,1]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,1]]}},"alternative-id":["10.1152\/ajpcell.00846.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00846.2025","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,1]]},"assertion":[{"value":"2025-11-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}