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Healthy muscle can regenerate from resident stem cells known as satellite cells (SCs). During homeostasis, individual SCs reside within a niche sandwiched between the basal lamina (BL) and sarcolemma, dispersed along the periphery of mature myofibers. The SC niche abuts capillaries embedded in extracellular matrix (ECM) containing fibroblasts and immune cells. With essential roles for each component of muscle tissue, cellular responses to injury are integrated and orchestrated during regeneration. Following physical trauma, chemical damage, or myotoxin exposure, inflammation ensues, with efferocytosis removing debris and creating space for new growth. Residual BL selectively guides regeneration of myofibers, capillaries, and nerves. SCs transition from quiescence to activation, proliferate as myoblasts, differentiate into myocytes (or undergo self-renewal), fuse into multinucleated myotubes, and return to quiescence while nascent myofibers mature. 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