{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T15:13:36Z","timestamp":1780326816117,"version":"3.54.1"},"reference-count":41,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["AG064143"],"award-info":[{"award-number":["AG064143"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG21332"],"award-info":[{"award-number":["P30AG21332"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012860","name":"Comprehensive Cancer Center at Wake Forest Baptist Medical Center","doi-asserted-by":"publisher","award":["P30CA012197"],"award-info":[{"award-number":["P30CA012197"]}],"id":[{"id":"10.13039\/100012860","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["AG069924"],"award-info":[{"award-number":["AG069924"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01RX004521"],"award-info":[{"award-number":["I01RX004521"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Center for Redox Biology in Medicine and Atrium Health Wake Forest Baptist Comprehensive Cancer Center"}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>Unacylated ghrelin prevents muscle wasting and maintains neuromuscular junction integrity and contractile function in cancer cachexia. It enhances mitochondrial respiratory capacity through elevated mitochondrial DNA copy number while limiting DNA mutation. It reduces mitochondrial reactive oxygen species (mtROS) generation, oxidative stress, and proteasome-mediated proteolysis-driven muscle degradation.<\/jats:p>","DOI":"10.1152\/ajpcell.00917.2025","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T14:50:41Z","timestamp":1776178241000},"page":"C1509-C1522","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Unacylated ghrelin counteracts mitochondrial dysfunction and neuromuscular junction disruption in cancer cachexia"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2743-7099","authenticated-orcid":false,"given":"Bumsoo","family":"Ahn","sequence":"first","affiliation":[{"name":"Atrium Health Wake Forest Baptist","place":["United States"]},{"name":"Wake Forest University School of Medicine","place":["United States"]},{"name":"Wake Forest University School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8460-8616","authenticated-orcid":false,"given":"Jonathan","family":"Wanagat","sequence":"additional","affiliation":[{"name":"University of California","place":["United States"]},{"name":"Veterans Administration Greater Los Angeles Healthcare System","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Cleary","sequence":"additional","affiliation":[{"name":"University of California","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1185-0695","authenticated-orcid":false,"given":"Hannah C.","family":"Ainsworth","sequence":"additional","affiliation":[{"name":"Atrium Health Wake Forest Baptist","place":["United States"]},{"name":"Wake Forest University School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Atrium Health Wake Forest Baptist","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.70104"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1589\/jpts.32.16"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.105"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061543"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/45230"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3144-z"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00558-6"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31128"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11122358"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201206-0982OC"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.109221"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00530.2019"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/cddiscovery.2017.77"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700126R"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.2337\/db15-1019"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14323"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.4103\/CJP.CJP_59_20"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.70458"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.610516"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12375"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.04.004"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1113\/JP288330"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glx058"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-222844"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11091264"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12615"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00472"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00487"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113150"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2010.01.003"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.02.021"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39920"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.05.018"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e06-05-0402"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay9592"},{"key":"B37","first-page":"2990","volume":"11","author":"Huot JR","year":"2021","journal-title":"Am J Cancer Res"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1172\/JCI128411"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.09.045"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160077"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-1205"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00917.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:44:30Z","timestamp":1780325070000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00917.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"alternative-id":["10.1152\/ajpcell.00917.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00917.2025","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]},"assertion":[{"value":"2025-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-10","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}