{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:12:46Z","timestamp":1785420766796,"version":"3.56.0"},"reference-count":39,"publisher":"American Physiological Society","issue":"3","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001592","name":"Higher Education Authority","doi-asserted-by":"publisher","award":["TUTF118"],"award-info":[{"award-number":["TUTF118"]}],"id":[{"id":"10.13039\/501100001592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:p>\n                    Many men with ED are resistant to treatment with phosphodiesterase 5 inhibitors (e.g., sildenafil); therefore, new treatments are required. We show that spontaneous contractions and phasic contractions of CCSM induced by low\/moderate concentrations of PE, and their underlying Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signals, are altered by K\n                    <jats:sub>V<\/jats:sub>\n                    7 channel modulators, whereas tonic contractions and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signals induced by high concentrations of PE are resistant to these compounds. This provides hope that K\n                    <jats:sub>V<\/jats:sub>\n                    7 channels may be targeted to treat ED.\n                  <\/jats:p>","DOI":"10.1152\/ajpcell.00980.2024","type":"journal-article","created":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T22:11:38Z","timestamp":1737324698000},"page":"C729-C742","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["K\n                    <sub>V<\/sub>\n                    7 channels modulate tension and calcium signaling in mouse corpus cavernosum"],"prefix":"10.1152","volume":"328","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8918-6009","authenticated-orcid":false,"given":"Mitchell","family":"Mercer","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01800zd49","id-type":"ROR","asserted-by":"publisher"}],"name":"Dundalk Institute of 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