{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:40:59Z","timestamp":1790422859823,"version":"4.1.0"},"reference-count":62,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/501100003819","name":"\u6e56\u5317\u7701\u79d1\u6280\u5385 | Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2022CFB599"],"award-info":[{"award-number":["2022CFB599"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:p>This study provides unprecedented insights into diabetic foot ulcer healing by demonstrating the novel immunoregulatory role of the TFAP2A-LIFR-Hippo-YAP signaling axis. Leveraging single-cell and bulk transcriptomics, we identify TFAP2A as a crucial regulator of macrophage M2 polarization, essential for wound healing and angiogenesis. These findings offer valuable mechanistic understanding and present TFAP2A as a promising therapeutic target for improving outcomes in chronic diabetic wounds.<\/jats:p>","DOI":"10.1152\/ajpcell.01067.2024","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T11:00:58Z","timestamp":1745319658000},"page":"C1921-C1940","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Mechanistic insights into Hippo-YAP pathway activation for enhanced DFU healing"],"prefix":"10.1152","volume":"328","author":[{"given":"Shaochun","family":"Zhang","sequence":"first","affiliation":[{"name":"The Central Hospital of Ezhou","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Wang","sequence":"additional","affiliation":[{"name":"The Central Hospital of Ezhou","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Xiong","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00vx54857","id-type":"ROR","asserted-by":"publisher"}],"name":"The Central Hospital of Ezhou","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jili","family":"Xing","sequence":"additional","affiliation":[{"name":"The Central Hospital of Ezhou","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8042-277X","authenticated-orcid":false,"given":"Ke","family":"Jing","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00vx54857","id-type":"ROR","asserted-by":"publisher"}],"name":"The Central Hospital of Ezhou","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3272"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202203308"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-022-04372-w"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v13.i12.1014"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.10578"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.744868"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/s13047-023-00610-6"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2015.04.002"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1221705"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.8879"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108176"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173090"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.34133\/research.0310"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01930"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000604"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S288090"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1186\/s13619-022-00152-5"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1049\/nbt2.12115"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-021-00146-0"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.03.005"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3390\/biom13010047"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115934"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113463"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-03015-7"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.08.015"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.01.015"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.736153"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-017-1145-4"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-022-00707-w"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.04.030"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01425-x"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2013.1248"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2019.1593645"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-86891-2"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-021-00598-2"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15701"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-1561-x"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00031.2009"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.13040"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1836"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18276-0"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.78046"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.03.028"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.22.13746"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2023.154759"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.05.004"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2940"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2023.154821"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-023-01910-6"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.01.010"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03606-x"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2021.04.003"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204561"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2021.05.006"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14102065"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-022-09748-8"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01756-x"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1186\/bcr3349"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2017.4102"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12082011"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-012-2068-7"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2561"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.01067.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T12:18:12Z","timestamp":1749644292000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.01067.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,1]]},"references-count":62,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6,1]]}},"alternative-id":["10.1152\/ajpcell.01067.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.01067.2024","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,1]]},"assertion":[{"value":"2025-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-16","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}