{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:32:35Z","timestamp":1760646755337},"reference-count":0,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[1991,8,1]]},"abstract":"<jats:p> K+ currents in freshly dispersed cells from rat myometrium at estrus were studied with the patch-clamp technique (whole cell). Three types of K+ currents were identified: 1) a fast-activating current (IKf), 2) a slowly activating current (IKs), and 3) a transient current (IKt). IKf had a half-activation voltage of 12 mV and a time constant of activation (tau on) of approximately 3 ms at +50 mV. IKs had a tau on of approximately 9 ms at +50 mV and a half-activation potential of 33 mV. Both IKf and IKs were sustained and became potentiated by the entrance of Ca2+ from the patch pipette. These two Ca(2+)-activated K+ currents were inhibited by 100 nM external charybdotoxin and were blocked by external tetraethylammonium (TEA, 2-20 mM). The third current (IKt) was transient, had a faster tau on (approximately 1 ms), and a decay phase with a time constant of approximately 8 ms at +50 mV. This current had a half-activation potential of 22 mV. IKt was not potentiated by intracellular Ca2+, was sensitive to 4-aminopyridine (1 mM), was insensitive to external charybdotoxin (100 nM) and TEA (2 mM), and spontaneously decreased with time. <\/jats:p>","DOI":"10.1152\/ajpcell.1991.261.2.c278","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T13:33:10Z","timestamp":1514122390000},"page":"C278-C284","source":"Crossref","is-referenced-by-count":23,"title":["Potassium currents in freshly dispersed myometrial cells"],"prefix":"10.1152","volume":"261","author":[{"given":"E.","family":"Piedras-Renteria","sequence":"first","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Baylor College ofMedicine, Houston, Texas 77030."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Stefani","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Baylor College ofMedicine, Houston, Texas 77030."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Toro","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Baylor College ofMedicine, Houston, Texas 77030."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.1991.261.2.C278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T19:46:17Z","timestamp":1718653577000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.1991.261.2.C278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,8,1]]}},"alternative-id":["10.1152\/ajpcell.1991.261.2.C278"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.1991.261.2.c278","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,8,1]]}}}