{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T07:59:54Z","timestamp":1769241594706,"version":"3.49.0"},"reference-count":0,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[1992,3,1]]},"abstract":"<jats:p> The regulation of Ca2+ current by intracellular Ca2+ was studied in isolated myocytes from the circular layer of canine gastric antrum. Ca2+ current was measured with the whole cell patch-clamp technique, and changes in cytoplasmic Ca2+ ([Ca2+]i) were simultaneously measured with indo-1 fluorescence. Ca2+ currents were activated by depolarization and inactivated despite maintained depolarization. Ca2+ current inactivation was fit with a double exponential function. Using Ba2+ or Na+ as charge carriers removed the fast component of inactivation, whereas enhanced intracellular buffering of Ca2+ did not remove the fast component. Ca2+ currents were associated with a rise in [Ca2+]i. The decrease in [Ca2+]i following repolarization was exponential, and during the relaxation of [Ca2+]i, Ca2+ current was inactivated. The inward current recovered with a similar time course as the decrease in [Ca2+]i, suggesting that [Ca2+]i regulates the basal availability of Ca2+ channels. These data support the hypothesis that, although [Ca2+]i may influence the resting level of inactivation, it is the \"submembrane\" compartment of [Ca2+]i that regulates the development of inactivation. <\/jats:p>","DOI":"10.1152\/ajpcell.1992.262.3.c691","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T13:08:42Z","timestamp":1514120922000},"page":"C691-C700","source":"Crossref","is-referenced-by-count":33,"title":["Regulation of calcium current by voltage and cytoplasmic calcium in canine gastric smooth muscle"],"prefix":"10.1152","volume":"262","author":[{"given":"F.","family":"Vogalis","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Nevada School of Medicine,Reno 89557."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. G.","family":"Publicover","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Nevada School of Medicine,Reno 89557."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. M.","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Nevada School of Medicine,Reno 89557."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.1992.262.3.C691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T19:43:59Z","timestamp":1718653439000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.1992.262.3.C691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,3,1]]}},"alternative-id":["10.1152\/ajpcell.1992.262.3.C691"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.1992.262.3.c691","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,3,1]]}}}