{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:22:30Z","timestamp":1771629750206,"version":"3.50.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[1994,2,1]]},"abstract":"<jats:p> The role of protein kinase C in the regulation of the mode of NaCl entry into Necturus gallbladder epithelial cells was determined from the rate and magnitude of ouabain-induced cell swelling in the presence of inhibitors. Stimulation of protein kinase C by phorbol ester increased the rate of cell swelling from the control value of 2.9% to 4.7%\/min and caused the predominant apical membrane transport mechanism for NaCl to switch from bumetanide-sensitive Na-Cl cotransport to amiloride-sensitive parallel exchange. Na-Cl cotransport could be restored as the predominant mode of NaCl entry by treatment of stimulated tissues with the kinase inhibitors 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7) and calphostin C. Therefore the mechanism of NaCl transport across the apical membrane can be controlled by the activity of protein kinase C. <\/jats:p>","DOI":"10.1152\/ajpcell.1994.266.2.c531","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T18:13:44Z","timestamp":1514139224000},"page":"C531-C535","source":"Crossref","is-referenced-by-count":14,"title":["Regulation of NaCl entry into Necturus gallbladder epithelium by protein kinase C"],"prefix":"10.1152","volume":"266","author":[{"given":"R.","family":"Dausch","sequence":"first","affiliation":[{"name":"Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung,and Blood Institute, National Institutes of Health, Bethesda, Maryland20892."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. R.","family":"Spring","sequence":"additional","affiliation":[{"name":"Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung,and Blood Institute, National Institutes of Health, Bethesda, Maryland20892."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.1994.266.2.C531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T19:40:23Z","timestamp":1718653223000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.1994.266.2.C531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,2,1]]}},"alternative-id":["10.1152\/ajpcell.1994.266.2.C531"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.1994.266.2.c531","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,2,1]]}}}