{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:06:19Z","timestamp":1718669179307},"reference-count":0,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[1994,10,1]]},"abstract":"<jats:p> The effects of increased extracellular Ca2+ concentration ([Ca2+]e) were examined on a delayed-rectifier K+ current (IK) and an inward-rectifier K+ current (IK1) in rabbit osteoclasts. Elevation of [Ca2+]e from 1.8 to 18 mM shifted the half point for IK activation by +11.5 mV and the voltage dependence of inactivation by +9.7 mV and slowed the rate of IK activation and deactivation. These effects of elevated [Ca2+]e on IK are consistent with screening of cell surface negative charge. However, elevation of [Ca2+]e increased the voltage-dependent kinetics of IK inactivation at all potentials tested, inconsistent with that predicted by simple surface charge theory. This finding suggests an additional, regulatory role for [Ca2+]e in the gating of IK channels. Some osteoclasts had an IK1, which was decreased when [Ca2+]e was raised from 1.8 to 18 mM. The physiological function of both types of K+ currents remains to be determined, and it is not clear whether these currents are involved with the coupling of cytosolic [Ca2+] to [Ca2+]e. <\/jats:p>","DOI":"10.1152\/ajpcell.1994.267.4.c1103","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T17:45:38Z","timestamp":1514137538000},"page":"C1103-C1111","source":"Crossref","is-referenced-by-count":13,"title":["Voltage-activated potassium currents of rabbit osteoclasts: effects of extracellular calcium"],"prefix":"10.1152","volume":"267","author":[{"given":"L. G.","family":"Hammerland","sequence":"first","affiliation":[{"name":"NPS Pharmaceuticals, Salt Lake City, Utah 84108."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. S.","family":"Parihar","sequence":"additional","affiliation":[{"name":"NPS Pharmaceuticals, Salt Lake City, Utah 84108."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. F.","family":"Nemeth","sequence":"additional","affiliation":[{"name":"NPS Pharmaceuticals, Salt Lake City, Utah 84108."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Sanguinetti","sequence":"additional","affiliation":[{"name":"NPS Pharmaceuticals, Salt Lake City, Utah 84108."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.1994.267.4.C1103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T19:40:14Z","timestamp":1718653214000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.1994.267.4.C1103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,10,1]]}},"alternative-id":["10.1152\/ajpcell.1994.267.4.C1103"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.1994.267.4.c1103","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,10,1]]}}}