{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:18:27Z","timestamp":1762899507871},"reference-count":0,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[1994,11,1]]},"abstract":"<jats:p> Mg deficiency results in loss of red blood cell glutathione and was thought to be due to decreased Mg-dependent synthesis. The effects of vitamin E, D-propranolol, and chloroquine on red blood cell glutathione levels in Mg-deficient rats were examined. Feeding the rats a Mg-deficient diet for 3 wk resulted in an approximately 80% decrease in serum Mg and a 55% loss of red blood cell glutathione; concomitantly, plasma thiobarbituric acid reactive (TBAR) materials rose 240%. All three drug treatments had no effect on the plasma Mg levels but significantly inhibited the rise in TBAR content and attenuated (60-80% effective) the loss of glutathione. Red blood cell ghost membranes from the Mg-deficient rats also exhibited 2.3-fold higher TBAR content, which was attenuated by vitamin E treatment. With isolated red blood cells from Mg-sufficient rats, loss of glutathione could be induced by a chemical oxyradical system. Direct protective effects were afforded by alpha-tocopherol and D-propranolol but not by chloroquine. The data suggest that 1) the loss of glutathione during Mg deficiency was due to increased oxidative degradation, 2) both vitamin E and D-propranolol protected by a membrane antiperoxidative action, and 3) chloroquine probably protected by diminishing prooxidant activity secondary to its inhibition of cytokine induction during Mg deficiency. <\/jats:p>","DOI":"10.1152\/ajpcell.1994.267.5.c1366","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T17:57:11Z","timestamp":1514138231000},"page":"C1366-C1370","source":"Crossref","is-referenced-by-count":30,"title":["Loss of red blood cell glutathione during Mg deficiency: prevention by vitamin E, D-propranolol, and chloroquine"],"prefix":"10.1152","volume":"267","author":[{"given":"I. T.","family":"Mak","sequence":"first","affiliation":[{"name":"Department of Physiology, George Washington University Medical Center,Washington, District of Columbia 20037."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Stafford","sequence":"additional","affiliation":[{"name":"Department of Physiology, George Washington University Medical Center,Washington, District of Columbia 20037."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. B.","family":"Weglicki","sequence":"additional","affiliation":[{"name":"Department of Physiology, George Washington University Medical Center,Washington, District of Columbia 20037."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.1994.267.5.C1366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T19:39:26Z","timestamp":1718653166000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.1994.267.5.C1366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1994,11,1]]}},"alternative-id":["10.1152\/ajpcell.1994.267.5.C1366"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.1994.267.5.c1366","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,11,1]]}}}