{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:07:26Z","timestamp":1718669246332},"reference-count":0,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[1995,7,1]]},"abstract":"<jats:p> We have previously demonstrated that the Na(+)-K+ pump on the basolateral membrane of the rabbit cortical collecting duct can function in the K+\/K+ exchange mode. Increasing intracellular phosphate in red blood cells inhibits the Na+ pump and increases K+\/K+ exchange. We found that maneuvers designed to increase intracellular phosphate in collecting duct cells caused an increase in K+\/K+ exchange. Subjecting the cells to a metabolic insult (cyanide) increased K+\/K+ exchange by the pump as judged by its ouabain sensitivity and lack of electrogenic or conductive characteristics. The results demonstrate that the rate of K+\/K+ exchange by the Na(+)-K+ pump can be altered by changes in intracellular phosphate over a range that is physiologically or pathologically achievable. The results also suggest a mechanism for inhibition of vectorial Na+ transport during metabolic stress. <\/jats:p>","DOI":"10.1152\/ajpcell.1995.269.1.c170","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T18:32:45Z","timestamp":1514140365000},"page":"C170-C178","source":"Crossref","is-referenced-by-count":2,"title":["K+ self-exchange by the Na+ pump: regulation by P(i) and metabolic perturbations"],"prefix":"10.1152","volume":"269","author":[{"given":"T.","family":"Nonaka","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. H.","family":"Warden","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. B.","family":"Stokes","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.1995.269.1.C170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T19:38:58Z","timestamp":1718653138000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.1995.269.1.C170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,7,1]]}},"alternative-id":["10.1152\/ajpcell.1995.269.1.C170"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.1995.269.1.c170","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,7,1]]}}}